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The Online Metabolic and Molecular Bases of Inherited Disease; Chapter 3.1: Metabolism and Metabolic Disease Resources on the Web, Page 1
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@MISC{_theonline,
author = {},
title = {The Online Metabolic and Molecular Bases of Inherited Disease; Chapter 3.1: Metabolism and Metabolic Disease Resources on the Web, Page 1},
year = {}
}
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Abstract
way information is shared. The Web has had a particularly profound effect in the life sciences, in which the rapid compilation and exchange of large volumes of information increasingly is becoming the norm. 2. Hundreds of online databases containing tens of gigabytes of biochemical or genetic data, along with hundreds of online tutorials covering thousands of biomedical subjects, are now available on the Web. These information-rich Web resources are becoming integral to many aspects of modern biology and biomedical research. 3. This chapter reviews some of the key online database that are dedicated to explaining or displaying up-to-date information on metabolism, metabolic pathways, and metabolic diseases, including (1) metabolic pathway databases, (2) metabolomic databases, (3) genetic and metabolic disease databases, (4) single-nucleotide polymorphism (SNP) and mutation databases, and (5) sequence databases. 4. Most online metabolic pathway databases are image-rich tools that are designed to facilitate the exploration of metabolism and metabolites across many different species. These databases also serve as a backbone to facilitate many practical applications in biology, including comparative genomics, targeted genome annotation, metabolite tracing, diet prediction, metabolic engineering, and metabolic simulation. Metabolic pathway databases often have served as the basis for understanding the genetic origins of newly discovered metabolic disorders, tracing the chemical or enzymatic origins of disease-associated metabolites, and suggesting potential dietary and drug interventions to treat inborn errors of metabolism. 5. Metabolomic databases such as the Human Metabolite Database (HMDB); (
Keyphrases
online metabolic metabolic disease resource molecular base inherited disease metabolomic database way information metabolic pathway database profound effect metabolic engineering online database image-rich tool online metabolic pathway database many aspect diet prediction comparative genomics metabolic disease metabolic pathway metabolic simulation genetic data up-to-date information rapid compilation sequence database life science mutation database key online database inborn error biomedical subject modern biology pathway database metabolic disease database many practical application enzymatic origin single-nucleotide polymorphism human metabolite database drug intervention large volume online tutorial information-rich web resource metabolic disorder metabolite tracing genome annotation disease-associated metabolite genetic origin many different specie biomedical research
