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A spatially unbiased atlas template of the human cerebellum. NeuroImage 33:127–138 (2006)
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@MISC{Diedrichsen06aspatially,
author = {Jörn Diedrichsen},
title = {A spatially unbiased atlas template of the human cerebellum. NeuroImage 33:127–138},
year = {2006}
}
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Abstract
This article presents a new high-resolution atlas template of the human, cerebellum and brainstem, based on the anatomy of 20 young healthy individuals. The atlas is spatially unbiased, i.e., the location of each structure is equal to the expected location of that structure across individuals in MNI space, a result that is cross-validated with an independent sample of 16 individuals. At the same time, the new template preserves the anatomical detail of cerebellar structures through a nonlinear atlas generation algorithm. In comparison to current whole-brain templates, it allows for an improved voxel-byvoxel normalization for functional MRI and lesion analysis. Alignment to the template requires that the cerebellum and brainstem are isolated from the surrounding tissue, a process for which an automated algorithm has been developed. Compared to normalization to the MNI whole-brain template, the new method strongly improves the alignment of individual fissures, reducing their spatial spread by 60%, and improves the overlap of the deep cerebellar nuclei. Applied to functional MRI data, the new normalization technique leads to a 5–15 % increase in peak t values and in the activated volume in the cerebellar cortex for movement vs. rest contrasts. This indicates that the new template significantly improves the overlap of functionally equivalent cerebellar regions across individuals. The template and software are freely available as an SPM-toolbox, which also allows users to relate the new template to the annotated volumetric
Keyphrases
new template unbiased atlas template human cerebellum new method new high-resolution atlas template functional mri equivalent cerebellar region improved voxel-byvoxel normalization mni space lesion analysis new normalization technique individual fissure current whole-brain template peak value cerebellar structure spatial spread rest contrast deep cerebellar nucleus activated volume young healthy individual functional mri data independent sample nonlinear atlas generation algorithm anatomical detail mni whole-brain template cerebellar cortex movement v
