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Copyright © 1993, American Society for Microbiology Neutralizing Antibodies in Cats Infected with Feline Immunodeficiency Virus (1992)
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@MISC{92copyright©,
author = {},
title = {Copyright © 1993, American Society for Microbiology Neutralizing Antibodies in Cats Infected with Feline Immunodeficiency Virus},
year = {1992}
}
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Abstract
Sera from cats experimentally infected with five isolates of feline immunodeficiency virus (FlY) from various geographical regions and from FIV enzyme-linked immunosorbent assay-seropositive field cats from four European countries neutralized the Petaluma strain of FIV (FlV-P), originally isolated in California, at high titers. In addition, FIV-P and a European isolate proved equally susceptible to neutralization by all sera tested. Coupled with observations by Fevereiro et al. (M. Fevereiro, C. Roneker, A. Laufs, L. Tavares, and F. de Noronha, J. Gen. Virol. 72:617-622, 1991), these findings indicate that most if not all FIV strains circulating in Europe and the United States share important neutralization-inducing epitopes. Feline immunodeficiency virus (FIV), a widespread cause of disease in domestic cats (2, 9, 24), shares many properties with human immunodeficiency virus (HIV) and is therefore considered a suitable model for studying aspects of AIDS pathogenesis and treatment which cannot be easily ad-dressed with humans (15, 19). Nonetheless, little is known about the ability of FIV to induce neutralizing antibodies (NA). Using a procedure based on infectivity inhibition,
Keyphrases
feline immunodeficiency virus american society cat infected microbiology neutralizing antibody high titer share many property european isolate various geographical region fiv strain human immunodeficiency virus aid pathogenesis european country suitable model infectivity inhibition domestic cat petaluma strain widespread cause
