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Analysing Six Types of Protein-Protein Interfaces (2003)
| Citations: | 101 - 7 self |
BibTeX
@MISC{Ofran03analysingsix,
author = {Yanay Ofran and Burkhard Rost and Bioinformatics (cb) Russ and North East Structural},
title = {Analysing Six Types of Protein-Protein Interfaces},
year = {2003}
}
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Abstract
statistically to which of the six types of interfaces a pool of 1000 residues belongs at 63 -- 100% accuracy. All interfaces differed significantly from the background of all residues in SWISS-PROT, from the group of surface residues, and from internal residues that were not involved in non-trivial interactions. Overall, our results suggest that the interface type could be predicted from sequence and that interface-type specific mean-field potentials may be adequate for certain applications. q 2003 Elsevier Science Ltd. All rights reserved Keywords: protein -- protein interaction; protein complexes; protein interface; protein folding; drug design *Corresponding authors Introduction Do different types of interactions use different biochemical mechanisms? Non-covalent contacts between residue sidechains are the basis for protein folding, protein assembly, and protein -- protein interaction. These contacts occur under many different conditions, and facilitate a variety of interacti
Keyphrases
six type protein-protein interface internal residue different biochemical mechanism interface-type specific mean-field potential protein interaction residue sidechains protein folding certain application non-covalent contact interface type non-trivial interaction many different condition protein assembly elsevier science ltd residue belongs surface residue
