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Functional specialization within rostral prefrontal cortex (area 10): A meta-analysis (2006)
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| Venue: | Journal of Cognitive Neuroscience |
| Citations: | 100 - 8 self |
BibTeX
@ARTICLE{Gilbert06functionalspecialization,
author = {Sam J. Gilbert and Stephanie Spengler and Jon S. Simons and J. Douglas Steele and Stephen M. Lawrie and Christopher D. Frith and Paul W. Burgess},
title = {Functional specialization within rostral prefrontal cortex (area 10): A meta-analysis},
journal = {Journal of Cognitive Neuroscience},
year = {2006},
pages = {932--948}
}
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Abstract
& One of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann’s area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one’s own emotions and mental states or those of other agents) were disproportionately associated with me-dial activations. Functional variation was also observed along a rostral–caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74 % for the three most common tasks; 45 % across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex. &
Keyphrases
rostral prefrontal cortex functional specialization me-dial activation functional variation chance level functional subdivision human brain common task mental state lateral activation activation peak rostral activation rostral caudal axis functional neuroimaging study episodic memory retrieval understood region classification algorithm training set caudal activation whereas study multiple-task coordination brodmann area considerable functional segregation
