DMCA
Differential Gene Expression of Primary Cultured Lymphatic and
BibTeX
@MISC{Vascular_differentialgene,
author = {Blood Vascular and Endothelial Cells},
title = {Differential Gene Expression of Primary Cultured Lymphatic and},
year = {}
}
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Abstract
Blood vascular endothelial cells (BECs) and the de-velopmentally related lymphatic endothelial cells (LECs) create complementary, yet distinct vascular networks. Each endothelial cell type interacts with flowing fluid and circulating cells, yet each vascular system has evolved specialized gene expression programs and thus both cell types display different phenotypes. BECs and LECs express distinct genes that are unique to their specific vascular microenviron-ment. Tumors also take advantage of the molecules that are expressed in these vascular systems to enhance their metastatic potential. We completed tran-scriptome analyses on primary cultured LECs and BECs, where each comparative set was isolated from the same individual. Differences were resolved in the expression of several major categories, such as cell adhesion molecules (CAMs), cytokines, and cytokine receptors. We have identified new molecules that are associated with BECs (e.g., claudin-9, CXCL11, neurexin-1, neurexin-2, and the neuronal growth factor regulator-1) and LECs (e.g., claudin-7, CD58, hyalu-ronan and proteoglycan link protein 1 (HAPLN1), and the poliovirus receptor–related 3 molecule) that may lead to novel therapeutic treatments for diseases of lymphatic or blood vessels, including metastasis of cancer to lymph nodes or distant organs.
Keyphrases
primary cultured lymphatic differential gene expression vascular system related lymphatic endothelial cell blood vessel endothelial cell type gene expression program novel therapeutic treatment cell adhesion molecule blood vascular endothelial cell distant organ several major category different phenotype distinct gene tran-scriptome analysis specific vascular microenviron-ment cytokine receptor neuronal growth factor regulator-1 poliovirus receptor comparative set distinct vascular network proteoglycan link protein new molecule metastatic potential cell type
