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Chemogenomics: An emerging strategy for rapid target and drug discovery (2004)
| Venue: | Nature Reviews Genetics |
| Citations: | 23 - 0 self |
BibTeX
@ARTICLE{Bredel04chemogenomics:an,
author = {Markus Bredel and Edgar Jacoby},
title = {Chemogenomics: An emerging strategy for rapid target and drug discovery},
journal = {Nature Reviews Genetics},
year = {2004}
}
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Abstract
Chemogenomics is an emerging discipline that combines the latest tools of genomics and chemistry and applies them to target and drug discovery. Its strength lies in eliminating the bottleneck that currently occurs in target identification by measuring the broad, conditional effects of chemical libraries on whole biological systems or by screening large chemical libraries quickly and efficiently against selected targets. The hope is that chemogenomics will concurrently identify and validate therapeutic targets and detect drug candidates to rapidly and effectively generate new treatments for many human diseases. TRANSCRIPTIONAL PROFILING The study of the transcriptome — the complete set of RNA transcripts that are produced by the genome at any one time — using high-throughput methods, such as microarray analysis.
Keyphrases
drug discovery rapid target microarray analysis whole biological system conditional effect rna transcript transcriptional profiling target identification chemical library new treatment many human disease detect drug candidate large chemical library therapeutic target complete set high-throughput method
