@MISC{Hu12background•, author = {Shuhua Hu}, title = {Background • Model}, year = {2012} }
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Abstract
� h(tj;q): corresponds to the observed part of the solution of a mathematical model (e.g., described by system of ODE, or PDE) with model parameter q at the measurement time point tj. � Ej: measurement error at measurement time point tj (random variable). � Yj: observation at measurement time point tj ( random variable). Under the assumption of Ej being i.i.d N(0,σ2), we have n ∏ [ 1 probability distribution model: g(y|θ) = √2πσ exp j=1