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Plasticity in the frequency representation of primary auditory cortex, following discrimination training in adult owl monkeys (1993)
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| Venue: | Journal of Neuroscience |
| Citations: | 149 - 2 self |
BibTeX
@ARTICLE{Recanzone93plasticityin,
author = {G. H. Recanzone and C. E. Schreiner and M. M. Merzenich},
title = {Plasticity in the frequency representation of primary auditory cortex, following discrimination training in adult owl monkeys},
journal = {Journal of Neuroscience},
year = {1993},
pages = {87--103}
}
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Abstract
Previous studies have shown that the tonotopic organization of primary auditory cortex is altered subsequent to restricted cochlear lesions (Robertson and Irvine, 1989) and that the topographic reorganization of the primary somatosensory cortex is correlated with changes in the perceptual acuity of the animal (Recanzone et al., 1992a-d). Here we report an increase in the cortical area of representation of a restricted frequency range in primary auditory cortex of adult owl monkeys that is correlated with the animal’s performance at a frequency discrimination task. Monkeys trained for several weeks to discriminate small differences in the frequency of sequentially presented tonal stimuli revealed a progressive improvement in performance with training. At the end of the training period, the tonotopic organization of Al was defined by recording multiple-unit responses at 70-258 cortical locations. These responses were compared to those derived from three normal monkeys and from two monkeys that received the same auditory stimuli but that were engaged in a tactile discrimination task. The cortical representation, the sharpness of tuning, and the latency of the response were greater for the behaviorally relevant frequencies of trained monkeys when compared to the same frequencies of control monkeys. The cortical area of representation was the only studied parameter that was correlated with behavioral performance. These results demonstrate that attended natural stimulation can modify the tonotopic organization of Al in the adult primate, and that this alteration is correlated with changes in perceptual acuity. [Key words: auditory cortex, primate, plasticity, behavior, physiology, discrimination training] Studies within the somatosensory system have shown that partial peripheral dennervation and restricted natural stimulation can result in a reorganization of the topographic representation of the body surface in the cerebral cortex (see Merzenich et al.,
Keyphrases
primary auditory cortex adult owl monkey frequency representation tonotopic organization discrimination training perceptual acuity cortical area natural stimulation cochlear lesion partial peripheral dennervation tactile discrimination task topographic representation frequency discrimination task cortical representation small difference control monkey primary somatosensory cortex somatosensory system multiple-unit response auditory cortex trained monkey cerebral cortex behavioral performance discrimination training study relevant frequency progressive improvement restricted frequency range several week 70-258 cortical location auditory stimulus body surface previous study training period topographic reorganization normal monkey tonal stimulus key word animal performance adult primate
