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A role for Cdc42 in macrophage chemotaxis (1998)
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| Venue: | J. Cell |
| Citations: | 119 - 6 self |
BibTeX
@ARTICLE{Allen98arole,
author = {William E. Allen and Daniel Zicha and Anne J. Ridley and Gareth E. Jones},
title = {A role for Cdc42 in macrophage chemotaxis},
journal = {J. Cell},
year = {1998},
pages = {141--1147}
}
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Abstract
Abstract. Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that Rho regulates cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively. We have now tested the roles of Cdc42, Rac, and Rho in colony stimulating factor-1 (CSF-1)–induced macrophage migration and chemotaxis using the Dunn chemotaxis chamber. Microinjection of constitutively activated RhoA, Rac1, or Cdc42 inhibited cell migration, presumably because the cells were unable to polarize significantly in response to CSF-1. Both Rho and Rac were required for CSF-1–induced migration, since migration speed was reduced to background levels in
