DMCA
The small GTPases Rho and Rac are required for the establishment of cadherindependent cell–cell contacts (1997)
| Venue: | J. Cell |
| Citations: | 95 - 3 self |
BibTeX
@ARTICLE{Braga97thesmall,
author = {Vania M. M. Braga and Laura M. Machesky and Alan Hall and Neil A. Hotchin},
title = {The small GTPases Rho and Rac are required for the establishment of cadherindependent cell–cell contacts},
journal = {J. Cell},
year = {1997},
pages = {137--1421}
}
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Abstract
Abstract. Cadherins are calcium-dependent cell–cell adhesion molecules that require the interaction of the cytoplasmic tail with the actin cytoskeleton for adhesive activity. Because of the functional relationship between cadherin receptors and actin filament organization, we investigated whether members of the Rho family of small GTPases are necessary for cadherin adhesion. In fibroblasts, the Rho family members Rho and Rac regulate actin polymerization to produce stress fibers and lamellipodia, respectively. In epithelial cells, we demonstrate that Rho and Rac are required for the establishment of cadherin-mediated cell–cell adhesion and the actin reorganization necessary to stabilize the receptors at sites of intercellular junctions. Blocking endogenous Rho or Rac selectively removed cadherin
Keyphrases
cadherindependent cell cell contact small gtpases rho adhesive activity actin filament organization stress fiber cadherin receptor calcium-dependent cell cell adhesion rho family member rho cytoplasmic tail small gtpases functional relationship rho family epithelial cell cadherin-mediated cell cell adhesion cadherin adhesion actin reorganization intercellular junction actin cytoskeleton endogenous rho actin polymerization
