Voxel-based morphometry using the ravens maps: Methods and validation using simulated longitudinal atrophy

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Voxel-based morphometry using the ravens maps: Methods and validation using simulated longitudinal atrophy (2001)

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by Christos Davatzikos , Ahmet Genc , Dongrong Xu , Susan M. Resnick

Venue:	NeuroImage
Citations:	94 - 30 self

BibTeX

@ARTICLE{Davatzikos01voxel-basedmorphometry,
    author = {Christos Davatzikos and Ahmet Genc and Dongrong Xu and Susan M. Resnick},
    title = {Voxel-based morphometry using the ravens maps: Methods and validation using simulated longitudinal atrophy},
    journal = {NeuroImage},
    year = {2001},
    pages = {1361--1369}
}

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Abstract

Statistical analysis of anatomical maps in a stereotaxic space has been shown to be a useful tool in population-based studies for quantifying local anatomical differences or changes, without a priori assumptions about the location and extent of the regions of interest. This paper presents an extension and validation of a previously published methodology, referred to as RAVENS, for characterizing regional atrophy in the brain. A new method for elastic, volume-preserving spatial normalization, which allows for accurate quantification of very localized atrophy, is used. The RAVENS methodology was tested on images with simulated atrophy within two gyri: precentral and superior temporal. It was found to accurately determine the regions of atrophy, despite their localized nature and the interindividual variability of cortical structures. Moreover, it was found to perform substantially better than the voxel-based morphology method of SPM’99. Improved sensitivity was achieved at the expense of human effort involved in defining a number of sulcal curves that serve as constraints on the 3D elastic warping. © 2001 Academic Press

Keyphrases

voxel-based morphometry raven map simulated longitudinal atrophy useful tool elastic warping priori assumption localized nature new method interindividual variability stereotaxic space accurate quantification cortical structure statistical analysis superior temporal anatomical map regional atrophy voxel-based morphology method academic press human effort localized atrophy sulcal curve raven methodology population-based study volume-preserving spatial normalization simulated atrophy local anatomical difference

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