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Effect of Autonomic Blockers on Heart Period Variability in Calves: Evaluation of the Sympatho-Vagal Balance (2001)
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BibTeX
@MISC{Després01effectof,
author = {G. Després and I. Veissier and A. Boissy},
title = {Effect of Autonomic Blockers on Heart Period Variability in Calves: Evaluation of the Sympatho-Vagal Balance},
year = {2001}
}
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Abstract
This study was designed to validate the measures of heart period variability for assessing of autonomic nervous system control in calves. Eight calves received an injection of either 0.5 mg/kg atenolol (sympathetic tone blockade), 0.2 mg/kg atropine sulfate (parasympathetic tone blockade), 0.5 mg/kg atenolol + 0.2 mg/kg atropine sulfate (double autonomic blockade) or saline. In the time-domain, we calculated the mean instantaneous heart rate (HR), mean of RR intervals (MeanRR), standard deviation of RR intervals (SDRR) and that of the difference between adjacent intervals (RMSSD). In the frequency-domain, the power of the spectral band 0-1 Hz (TPW), the power of the 0-0.15 Hz band (LF), that of the 0.15-1 Hz band (HF), and the LF/HF ratio were considered. The net vago-sympathetic effect (VSE) was calculated as the ratio of MeanRR in a defined situation to MeanRR during the double blockade. Atenolol injection had no effect on cardiac activity, whereas atropine induced large modifications which were moderated when atenolol was administered at the same time. VSE, HR, MeanRR and RMSSD were found to be valid indicators of the parasympathetic tone of calves because of large variations due to the drug and low individual variations. No measure reflected the sympathetic tone. Key words Autonomic nervous system • Heart period • Cholinergic antagonists • Adrenergic antagonists • Calves
Keyphrases
heart period variability autonomic blocker sympatho-vagal balance atropine sulfate rr interval sympathetic tone net vago-sympathetic effect mean instantaneous heart rate adjacent interval low individual variation parasympathetic tone blockade defined situation 15-1 hz band large modification parasympathetic tone atenolol injection valid indicator lf hf ratio mg kg spectral band 0-1 hz autonomic nervous system control cardiac activity sympathetic tone blockade hz band double blockade standard deviation mg kg atenolol large variation
