DMCA
3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometry (2006)
BibTeX
@MISC{Toga063dpattern,
author = {Arthur W. Toga and Paul M. Thompson A},
title = {3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometry},
year = {2006}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Fragile X syndrome (FraX), a genetic neurodevelopmental disorder, results in impaired cognition with particular deficits in executive function and visuo-spatial skills. Here we report the first detailed 3D maps of the effects of the Fragile X mutation on brain structure, using tensor-based morphometry. TBM visualizes structural brain deficits automatically, without time-consuming specification of regions-ofinterest. We compared 36 subjects with FraX (age: 14.66±1.58 S.D., 18 females/18 males), and 33 age-matched healthy controls (age: 14.67± 2.2 S.D., 17 females/16 males), using high-dimensional elastic image registration. All 69 subjects ’ 3D T1-weighted brain MRIs were spatially deformed to match a high-resolution single-subject average MRI scan in ICBM space, whose geometry was optimized to produce a minimal deformation target. Maps of the local Jacobian determinant (expansion factor) were computed from the deformation fields. Statistical maps showed increased caudate (10 % higher; p=0.001) and lateral ventricle
Keyphrases
tensor-based morphometry fragile syndrome brain abnormality minimal deformation target particular deficit brain structure age-matched healthy control icbm space high-dimensional elastic image registration lateral ventricle deformation field visuo-spatial skill genetic neurodevelopmental disorder executive function fragile mutation t1-weighted brain mri expansion factor time-consuming specification increased caudate local jacobian determinant impaired cognition structural brain deficit statistical map
