RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates.

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. (2006)

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by Andreas Pichlmair , Oliver Schulz , Choon Ping Tan , Tanja I Näslund , Peter Liljeström , Friedemann Weber , Caetano Reis E Sousa

Venue:	Science
Citations:	217 - 6 self

BibTeX

@ARTICLE{Pichlmair06rig-i-mediatedantiviral,
    author = {Andreas Pichlmair and Oliver Schulz and Choon Ping Tan and Tanja I Näslund and Peter Liljeström and Friedemann Weber and Caetano Reis E Sousa},
    title = {RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates.},
    journal = {Science},
    year = {2006},
    pages = {997--1001}
}

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Abstract

Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes RIG-I and MDA5. Here, we show that influenza A virus infection does not generate dsRNA and that RIG-I is activated by single stranded (ss) viral genomic RNA bearing 5' phosphates. This is blocked by the influenza protein NS1, which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense uncapped RNA evolved as a means of self/nonself discrimination by the innate immune system.

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