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The SWISS-MODEL Workspace: A web-based environment for protein structure homology modelling (2005)
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| Venue: | BIOINFORMATICS |
| Citations: | 574 - 5 self |
BibTeX
@MISC{Arnold05theswiss-model,
author = {Konstantin Arnold and Lorenza Bordoli and Torsten Schwede and et al.},
title = {The SWISS-MODEL Workspace: A web-based environment for protein structure homology modelling},
year = {2005}
}
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Abstract
Motivation: Homology models of proteins are of great interest for planning and analyzing biological experiments when no experimental three-dimensional structures are available. Building homology models requires specialized programs and up-to-date sequence and structural databases. Integrating all required tools, programs and databases into a single web-based workspace facilitates access to homology modelling from a computer with web connection without the need of downloading and installing large program packages and databases. Results: SWISS-MODEL Workspace is a web-based integrated service dedicated to protein structure homology modelling. It assists and guides the user in building protein homology models at different levels of complexity. A personal working environment is provided for each user where several modelling projects can be carried out in parallel. Protein sequence and structure databases necessary for modelling are accessible from the workspace and are updated in regular intervals. Tools for template selection, model building, and structure quality evaluation can be invoked from within the workspace. Workflow and usage of the workspace are illustrated by modelling human Cyclin A1 and human Transmembrane Protease
Keyphrases
swiss-model workspace protein structure homology web-based environment structural database building protein homology model human cyclin a1 building homology model experimental three-dimensional structure single web-based workspace template selection regular interval web connection different level several modelling project protein sequence structure quality evaluation model building great interest specialized program structure database web-based integrated service large program package human transmembrane protease up-to-date sequence personal working environment homology model required tool structure homology biological experiment
