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A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs (2007)
| Venue: | J. Cell Biol |
| Citations: | 20 - 0 self |
BibTeX
@TECHREPORT{Mosher07amutation,
author = {Dana S. Mosher and Pascale Quignon and Carlos D. Bustamante and Nathan B. Sutter and Cathryn S. Mellersh and Heidi G. Parker and Elaine A. Ostrander},
title = {A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs},
institution = {J. Cell Biol},
year = {2007}
}
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Abstract
Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation inMSTN found in the whippet dog breed that results in a double-muscled phenotype known as the ‘‘bully’ ’ whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion in the third exon ofMSTN leading to a premature stop codon at amino acid 313. Individuals carrying only one copy of the mutation are, on average, more muscular than wild-type individuals (p 7.43 3 106; Kruskal-Wallis Test) and are significantly faster than individuals carrying the wild-type genotype in competitive racing events (Kendall’s nonparametric measure, s 0.3619; p ’ 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance.
