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Defining the transcriptomic landscape of Candida glabrata by RNA-Seq (2014)
BibTeX
@MISC{Weber14definingthe,
author = {Michael Weber and Fabian Horn and Patricia Sieber and Daniela Hellwig and Konstantin Riege and Manja Marz and Ronny Martin and Reinhard Guthke and Oliver Kurzai},
title = {Defining the transcriptomic landscape of Candida glabrata by RNA-Seq},
year = {2014}
}
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Abstract
Candida glabrata is the second most common pathogenic Candida species and has emerged as a leading cause of nosocomial fungal infections. Its reduced susceptibility to antifungal drugs and its close relationship to Saccharomyces cerevisiae make it an interesting research focus. Although its genome sequence was published in 2004, little is known about its transcriptional dynamics. Here, we provide a detailed RNA-Seq-based analysis of the transcriptomic landscape of C. glabrata in nutrient-rich media, as well as under nitrosative stress and during pH shift. Using RNA-Seq data together with state-of-the-art gene prediction tools, we refined the annotation of the C. glabrata genome and predicted
