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Changes in network activity with the progression of Parkinson's disease (2007)
| Venue: | Brain |
| Citations: | 6 - 0 self |
BibTeX
@ARTICLE{Huang07changesin,
author = {Chaorui Huang and Andrew Feigin and Martin Lesser and Yilong Ma and Michael Pourfar and Vijay Dhawan and David Eidelberg},
title = {Changes in network activity with the progression of Parkinson's disease},
journal = {Brain},
year = {2007},
pages = {1834--1846}
}
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Abstract
Parkinson’s disease (PD) is associated with abnormal activity in spatially distributed neural systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET studies have demonstrated that this illness is characterized by a set of reproducible functional brain networks that correlate with these clinical features.The time at which these abnormalities appear is unknown, as is their relationship to concurrent clinical and dopaminergic indices of disease progression. In this longitudinal study, 15 early stage PD patients (age 58.010.2 years;Hoehn and Yahr Stage 1.2 0.3) were enrolled within 2 years of diagnosis. The subjects underwent multitracer PET imaging at baseline, 24 and 48 months. At each timepoint they were scanned with [18F]-fluorodeoxyglucose (FDG) to assess longitudinal changes in regional glucose utilization and in the expression of the PD-related motor (PDRP) and cognitive metabolic covariance patterns (PDCP). At each timepoint the subjects also underwent PET imaging with [18F]-fluoropropyl CIT (FP-CIT) to quantify longitudinal changes in caudate and putamen dopamine transpor-ter (DAT) binding. Regionalmetabolic changes across the three timepoints were localized using statistical para-metric mapping (SPM). Longitudinal changes in regional metabolism and network activity, caudate/putamen DAT binding, and Unified Parkinson’s Disease Rating Scale (UPDRS) motor ratings were assessed using repeated measures analysis of variance (RMANOVA). Relationships between these measures of disease
Keyphrases
network activity longitudinal change pd-related motor early stage pd patient distributed neural system dopaminergic index abnormal activity motor rating unified parkinson disease rating scale regional metabolism yahr stage cognitive manifestation reproducible functional brain network underwent pet putamen dat binding subject underwent multitracer pet imaging clinical feature cognitive metabolic covariance pattern parkinson disease metabolic pet study statistical para-metric mapping regionalmetabolic change repeated measure analysis disease progression fluoropropyl cit regional glucose utilization longitudinal study
