DMCA
Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease (1996)
| Citations: | 10 - 0 self |
BibTeX
@MISC{Winkler96short-termgdnf,
author = {Christian Winkler and Hansjörg Sauer and Chong S. Lee and Anders Björklund},
title = {Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease},
year = {1996}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neuroprotective effects on dopamine (DA) neurons in vivo. Here we report long-term rescue of nigral DA neurons after delayed short-term GDNF administration in a rat lesion model that reproduces the slowly progressing degenerative process seen in Parkinson’s disease. GDNF injected close to the substantia nigra provided near-complete protection and persistent survival of the lesioned nigral neurons for at least 4 months after discontinuation of GDNF treatment. Long-term rescue of the nigral cells, however, was not accompanied by any significant reinnervation of the lesioned striatal target or any signs of functional recovery in either drug-induced or spontaneous motor behaviors. We conclude that not only preservation of the nigral DA neurons but also restoration of striatal DA function is necessary for functional recovery in the rat Parkinson model. Key words: GDNF; substantia nigra; striatum; neurodegeneration; behavior; Parkinson’s disease
Keyphrases
long-term rescue rat model lesioned nigral dopaminergic neuron short-term gdnf treatment nigral da neuron functional recovery substantia nigra delayed short-term gdnf administration striatal da function rat lesion model parkinson disease lesioned striatal target glial cell line-derived neurotrophic factor progressing degenerative process lesioned nigral neuron near-complete protection significant reinnervation rat parkinson model neuroprotective effect persistent survival nigral cell key word spontaneous motor behavior gdnf treatment
