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doi:10.1155/2011/548123 Research Article Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [ 18 F]MK-9470
BibTeX
@MISC{Verdur_doi:10.1155/2011/548123research,
author = {Mathieu Verdur and Vu Nguyen and Daniela Stark and David Zahra and Marie-claude Gregoire and Ivan Greguric and Katerina Zavitsanou},
title = {doi:10.1155/2011/548123 Research Article Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [ 18 F]MK-9470},
year = {}
}
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Abstract
Copyright © 2011 Mathieu Verdurand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Despite the important role of cannabinoid CB1 receptors (CB1R) in brain development, little is known about their status during adolescence, a critical period for both the development of psychosis and for initiation to substance abuse. In the present study, we assessed the ontogeny of CB1R in adolescent and adult rats in vivo using positron emission tomography with [ 18 F]MK-9470. Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [ 18 F]MK-9470 values between the two groups revealed a main effect of age (F(1, 109) = 5.0, P = 0.02) on [ 18 F]MK-9470 absolute binding (calculated as percentage of injected dose) with adult estimated marginal means being higher compared to adolescents amongst 11 brain regions. This finding was confirmed using in vitro autoradiography with [ 3 H]CP55,940 (F(10, 99) = 140.1, P<0.0001). This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period. 1.
Keyphrases
adult rat cannabinoid cb1 receptor binding research article comparison positron emission tomography study using unrestricted use brain development mk-9470 absolute binding present study neuroreceptor system important role cannabinoid cb1 receptor mathieu verdurand original work critical period ontogenetic pattern mk-9470 value body weight open access article main effect brain region creative common attribution license marginal mean vitro autoradiography substance abuse injected dose positron emission tomography
