BibTeX
@MISC{Biosynthesis_pump,
author = {Fig Cell-wall Biosynthesis and Gly Gly Glyglyl-lys},
title = {P UMP Cytoplasm Lip id II},
year = {}
}
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Abstract
The soluble precursor molecule of the peptidoglycan is formed in the cytoplasm. In a second step the N-acetylmuramyl-pentapeptide moiety is transferred to a membrane lipid carrier and coupled to N-acetylglucosamine. In S. aureus most of the glutamate residues of the pentapeptide chain are amidated in the course of biosynthesis and an interpeptide bridge of five glycine residues is coupled to the L-lysine residue. This building block, called lipid II, is transported to the outside. The disaccharide unit is linked to the nascent carbohydrate chain of the peptidoglycan by the transglycosylases (1). Crosslinkage between adjacent chains is brought about by a transpeptidation reaction between most of the peptide units mediated by the penicillin binding proteins (PBPs) (2). The energy for transpeptidation is taken from the D-alanyl-D-alanine bond thereby releasing the terminal D-alanine. 1 L ip id I
Keyphrases
ump cytoplasm lip id ii d-alanyl-d-alanine bond thereby ip id pentapeptide chain lipid ii nascent carbohydrate chain second step penicillin binding protein adjacent chain glycine residue terminal d-alanine membrane lipid carrier disaccharide unit l-lysine residue transpeptidation reaction n-acetylmuramyl-pentapeptide moiety peptide unit glutamate residue interpeptide bridge building block soluble precursor molecule
