DMCA
Development of a Compact MRI System for Trabecular Bone Microstructure Measurements of the Distal Radius
BibTeX
@MISC{H_developmentof,
author = {Shinya H and Sadanori Tomiha and Tomoyuki Haishi and Katsumi Kose},
title = {Development of a Compact MRI System for Trabecular Bone Microstructure Measurements of the Distal Radius},
year = {}
}
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Abstract
A compact MRI system for trabecular bone (TB) microstructure measurements of the distal radius was developed using a 1.0 T permanent magnet and a compact MRI console. TB microstruc-ture of the distal radius was clearly visualized using a three-dimensional (3D) driven equilibrium spin-echo (DESE) sequence in 23 min. The image obtained had a sufficient spatial resolution (150 m 150 m 500 m) and signal-to-noise ratio (SNR) (approximately 10) for 3D bone microstructure analysis. The system demonstrated the feasibility of using a permanent mag-net compact MRI system as a clinical instrument for bone microstructure measurements of the distal radius. Magn Re-son Med 58:225–229, 2007. © 2007 Wiley-Liss, Inc. Key words: dedicated MRI; distal radius; trabecular bone; bone microstructure; driven equilibrium spin-echo. Measurements of trabecular bone (TB) microstructure are essential for assessment of bone fracture risk and evalua-tion of drug therapy in osteoporosis (1–6). TB microstruc-ture has been measured using extremity RF coils and so-phisticated imaging pulse sequences in whole-body MRI systems (7–12). Recently, a compact MRI for the human finger (13) and high-resolution X-ray CT systems for hu-man extremities have been reported as new instruments for TB microstructure measurements (14). Because X-ray CT systems use ionizing radiation, high-resolution MRI systems have a definite advantage in terms of patient safety. Although the finger MRI system has ad-vantages of spatial resolution and compactness, the finger is not a well-accepted site for bone microstructure evalu-ation. Therefore, if we can construct a compact MRI to measure a well-accepted site, such as the distal radius, tibia, and calcaneus, for TB microstructure analysis, the system will be a useful instrument for diagnosis of osteo-porosis. In this work we have developed a compact MRI for measurements of the distal radius using a 1.0 T permanent magnet and a compact MRI console. Using this system, we have successfully obtained high-resolution images of the distal radius that could be used for TB microstructure analysis.
Keyphrases
distal radius compact mri system compact mri trabecular bone trabecular bone microstructure measurement permanent magnet tb microstructure analysis compact mri console tb microstruc-ture well-accepted site bone fracture risk bone microstructure evalu-ation whole-body mri system microstructure measurement high-resolution mri system bone microstructure measurement hu-man extremity so-phisticated imaging pulse sequence tb microstructure measurement bone microstructure patient safety signal-to-noise ratio extremity rf coil driven equilibrium spin-echo human finger useful instrument drug therapy finger mri system permanent mag-net compact mri system magn re-son med definite advantage high-resolution x-ray ct system sufficient spatial resolution new instrument x-ray ct system high-resolution image clinical instrument bone microstructure analysis key word spatial resolution
