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GENOME-WIDE CENSUS AND EXPRESSION PROFILING OF CHICKEN NEUROPEPTIDE AND PROHORMONE CONVERTASE GENES BY
BibTeX
@MISC{Delfino_genome-widecensus,
author = {Kristin Renee Delfino},
title = {GENOME-WIDE CENSUS AND EXPRESSION PROFILING OF CHICKEN NEUROPEPTIDE AND PROHORMONE CONVERTASE GENES BY},
year = {}
}
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Abstract
Neuropeptides regulate cell-cell signaling and influence many biological processes in vertebrates, including development, growth, and reproduction. The complex processing of neuropeptides from prohormone proteins by prohormone convertases, combined with the evolutionary distance between the chicken and mammalian species that have experienced extensive neuropeptide research, has led to the empirical confirmation of only 18 chicken prohormone proteins. To expand our knowledge of the neuropeptide and prohormone convertase gene complement, we performed an exhaustive survey of the chicken genomic, EST, and proteomic databases using a list of 95 neuropeptide and 7 prohormone convertase genes known in other species. Analysis of the EST resources and 22 microarray studies offered a comprehensive portrait of gene expression across multiple conditions. Five neuropeptide genes (apelin, cocaine- and amphetamine-regulated transcript protein, insulin-like 5, neuropeptide S, and neuropeptide B) previously unknown in chicken were identified and 62 genes were confirmed. Although most neuropeptide gene families known in the human are present in the chicken, several genes are not present in the chicken. Conversely, several chicken neuropeptide genes are absent from mammalian species, including C-RF amide, c-type natriuretic peptide 1
Keyphrases
mammalian specie exhaustive survey cell-cell signaling c-rf amide neuropeptide gene family chicken prohormone est resource c-type natriuretic peptide prohormone convertase gene complex processing influence many biological process evolutionary distance gene expression neuropeptide gene several gene several chicken neuropeptide gene empirical confirmation chicken genomic prohormone convertases prohormone convertase gene complement extensive neuropeptide research amphetamine-regulated transcript protein prohormone protein proteomic database multiple condition microarray study comprehensive portrait
