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Identification, replication, and functional fine-mapping of expression quantitative trait Loci in primary human liver tissue. PLoS genetics 7: e1002078 (2011)
| Citations: | 28 - 0 self |
BibTeX
@MISC{Innocenti11identification,replication,,
author = {Federico Innocenti and Gregory M. Cooper and Ian B. Stanaway and Eric R. Gamazon and Joshua D. Smith and Snezana Mirkov and Jacqueline Ramirez and Wanqing Liu and Yvonne S. Lin and Cliona Moloney and Shelly Force and Nathan D. Trinklein and Erin Schuetz and Deborah A. Nickerson and Ken E. Thummel and Mark J. Rieder and Allan E. Rettie and Mark J. Ratain and Nancy J. Cox and Christopher D. Brown},
title = {Identification, replication, and functional fine-mapping of expression quantitative trait Loci in primary human liver tissue. PLoS genetics 7: e1002078},
year = {2011}
}
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Abstract
The discovery of expression quantitative trait loci (‘‘eQTLs’’) can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that,30 % of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and we quantified
