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Reporting Discrepancies Between the ClinicalTrials.gov Results Database and Peer-Reviewed Publications
BibTeX
@MISC{_reportingdiscrepancies,
author = {},
title = {Reporting Discrepancies Between the ClinicalTrials.gov Results Database and Peer-Reviewed Publications},
year = {}
}
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Abstract
Background: ClinicalTrials.gov requires reporting of result summa-ries for many drug and device trials. Purpose: To evaluate the consistency of reporting of trials that are registered in the ClinicalTrials.gov results database and published in the literature. Data Sources: ClinicalTrials.gov results database and matched pub-lications identified through ClinicalTrials.gov and a manual search of 2 electronic databases. Study Selection: 10 % random sample of phase 3 or 4 trials with results in the ClinicalTrials.gov results database, completed before 1 January 2009, with 2 or more groups. Data Extraction: One reviewer extracted data about trial design and results from the results database and matching publications. A subsample was independently verified. Data Synthesis: Of 110 trials with results, most were industry-sponsored, parallel-design drug studies. The most common incon-sistency was the number of secondary outcome measures reported (80%). Sixteen trials (15%) reported the primary outcome descrip-tion inconsistently, and 22 (20%) reported the primary outcome value inconsistently. Thirty-eight trials inconsistently reported the number of individuals with a serious adverse event (SAE); of these, 33 (87%) reported more SAEs in ClinicalTrials.gov. Among the 84 trials that reported SAEs in ClinicalTrials.gov, 11 publications did not mention SAEs, 5 reported them as zero or not occurring, and 21 reported a different number of SAEs. Among 29 trials that reported deaths in ClinicalTrials.gov, 28 % differed from the matched publication. Limitation: Small sample that included earliest results posted to the database. Conclusion: Reporting discrepancies between the ClinicalTrials.gov results database and matching publications are common. Which source contains the more accurate account of results is unclear, although ClinicalTrials.gov may provide a more comprehensive de-scription of adverse events than the publication.
Keyphrases
gov result database peer-reviewed publication matching publication device trial primary outcome value result database many drug mention saes study selection data synthesis random sample thirty-eight trial accurate account small sample serious adverse event result summa-ries different number manual search common incon-sistency trial design data source electronic database adverse event data extraction sixteen trial comprehensive de-scription secondary outcome measure primary outcome descrip-tion parallel-design drug study
