DMCA
Integration of Direct Methods With Macromolecular Crystallographic Techniques
BibTeX
@MISC{Giacovazzo_integrationof,
author = {C. Giacovazzo and D. Siliqi and J. Gonzalez-platas},
title = {Integration of Direct Methods With Macromolecular Crystallographic Techniques},
year = {}
}
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Abstract
The role of direct methods in macromolecular crystallography is discussed. The common belief that such methods will still remain marginal is rejected. Different sectors are analyzed. A direct procedure for phasing reflections when diffraction data of one isomorphous derivative are available is briefly described. The applications to experimental data of some test structures succeeded, and suggest that direct methods are competitive with traditional SIR techniques. Attention is also devoted to a formula which is able to recover the total from a partial structure. Direct methods can play a central role also for expanding (and refining) phases from derivative to native resolution, and can constitute an alternative to traditional molecular replacement techniques. 1 Introduction The use of traditional direct methods for solving macromolecular crystal structures or for refining phases was initiated several years ago. It was soon realized that Sayre equation, tangent formula, Karle-Hauptman d...
Keyphrases
direct method macromolecular crystallographic technique partial structure macromolecular crystallography common belief traditional molecular replacement technique refining phase different sector native resolution direct procedure traditional direct method several year test structure tangent formula central role sayre equation isomorphous derivative macromolecular crystal structure diffraction data traditional sir technique
