DMCA
Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
| Venue: | Hum. Brain Mapp |
| Citations: | 11 - 1 self |
BibTeX
@ARTICLE{Morra_automated3d,
author = {Jonathan H. Morra and Zhuowen Tu and Liana G. Apostolova and Amity E and Christina Avedissian and Sarah K. Madsen and Neelroop Parikshak and Xue Hua and Arthur W. Toga and Clifford R. Jack and Norbert Schuff and Michael W. Weiner and Paul M. Thompson and The Alzheimer’s Disease Neuroimaging Initiative},
title = {Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls},
journal = {Hum. Brain Mapp},
year = {},
pages = {2766--2788}
}
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Abstract
We used a new method we developed for automated hippocampal segmentation, called the auto context model (ACM), to analyze brain MRI scans of 400 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). After training the classifier on 21 hand-labeled expert segmentations, we created binary maps of the hippocampus for three age- and sex-matched groups: 100 subjects with Alzheimer’s disease (AD), 200 with mild cognitive impairment (MCI) and 100 elderly controls (mean age: 75.84; SD: 6.64). Hippocampal traces were converted to parametric surface meshes and a radial atrophy mapping technique was used to compute average surface models and local statistics of atrophy. Surface-based statistical maps visualized links between regional atrophy and diagnosis (MCI versus controls: p = 0.008; MCI versus AD: p = 0.001), mini-mental state exam (MMSE) scores, and global and sum-of-boxes clinical dementia rating scores (CDR; all p < 0.0001, corrected). Right but not left hippocampal atrophy was associated with geriatric depression scores (p = 0.004, corrected); hippocampal atrophy was not associated with subsequent decline in MMSE and CDR scores, educational level, ApoE genotype, systolic or diastolic blood pressure measures, or homocysteine. We gradually reduced sample sizes
Keyphrases
hippocampal atrophy mild cognitive impairment elderly control clinical correlate geriatric depression score brain mri scan cdr score new method mini-mental state exam apoe genotype educational level mci versus ad sex-matched group sum-of-boxes clinical dementia rating score sample size alzheimer disease hand-labeled expert segmentation regional atrophy diastolic blood pressure measure hippocampal segmentation hippocampal trace binary map surface mesh auto context model alzheimer disease neuroimaging initiative subsequent decline local statistic mean age radial atrophy mapping technique mci versus control surface-based statistical map average surface model
