DMCA
Molecular Cancer BioMed Central Review Role of APC and DNA mismatch repair genes in the development of (2003)
BibTeX
@MISC{Cancers03molecularcancer,
author = {Colorectal Cancers and Satya Narayan and Deodutta Roy and Open Access},
title = {Molecular Cancer BioMed Central Review Role of APC and DNA mismatch repair genes in the development of},
year = {2003}
}
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Abstract
all media for any purpose, provided this notice is preserved along with the article's original URL. Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S. in 2003, accounting for about 10% of cancer deaths. Among the colon cancer patients, hereditary risk contributes approximately 20%. The main inherited colorectal cancers are the familial adenomatous polyposis (FAP) and the hereditary nonpolyposis colorectal cancers (HNPCC). The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes. The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers. Background Prognosis of colorectal cancer depends on the stage of the tumor at the time of diagnosis, with surgery being the most effective treatment. Colorectal cancers develop
Keyphrases
colorectal cancer repair gene colon cancer patient mmr gene product effective treatment cancer death main inherited colorectal cancer american cancer society hereditary nonpolyposis colorectal cancer background prognosis common cause western hemisphere cancer-related death familial adenomatous polyposis new case colon cancer hereditary risk contributes original url adenomatous polyposis coli
