by MD Yoshihiro Fukumoto , MD Norikazu Yamada , MD Hiromi Matsubara , PhD; Minori Mizoguchi , PhD; Kazuaki Uchino , MD; Atsushi Yao , PhD; Yasuki Kihara , PhD; Mitsuhiro Kawano , MD Hiroshi Watanabe , PhD; Yutaka Takeda , PhD; Takeshi Adachi , PhD; Shinobu Osanai , PhD; Nobuhiro Tanabe , MD Teruo Inoue , PhD; Akihiro Kubo , Yuri Ota , PhD; Koichiro Fukuda , MD Takeshi Nakano , PhD; Hiroaki Shimokawa