Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model

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Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model

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by Damian D. Mcleod , Daniel J. Beard , Mark W. Parsons , Christopher R. Levi , Mike B. Calford , Neil J. Spratt

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283	Reversible middle cerebral artery occlusion without craniectomy in rats. - EZ, PR, et al. - 1989 (Show Context) Citation Context ...occlusion of the MCA in the rat is the most common experimental model of stroke. This technique is performed by inserting an occluding monofilament suture via the ICA to occlude the origin of the MCA =-=[4]-=-. Advantages of this technique include lack of craniotomy and control over occlusion and reperfusion. One disadvantage of this model is the large variability in infarct volume. Factors thought to infl...
6	Arterial patterns of the rat rhinencephalon and related structures. Exp Neurol 49 - Coyle - 1975 (Show Context) Citation Context ...n particular the anterior choroidal artery (AChA). The AChA supplies blood to the globus pallidus, the internal capsule, choroid plexus and has anastomotic connections with the MCA in rats and humans =-=[1,2]-=-. Despite the AChA territory being well defined, there is substantial variability in the origin of this vessel. The AChA predominantly originates from the internal carotid artery (ICA) in close proxim...
4	Deep perforators from the carotid system: template of the vascular territories. Arch Neurol. 1990;47: 1097–1100. Kumral et al - JA, Bogousslavsky, et al. - 1999 (Show Context) Citation Context ...n particular the anterior choroidal artery (AChA). The AChA supplies blood to the globus pallidus, the internal capsule, choroid plexus and has anastomotic connections with the MCA in rats and humans =-=[1,2]-=-. Despite the AChA territory being well defined, there is substantial variability in the origin of this vessel. The AChA predominantly originates from the internal carotid artery (ICA) in close proxim...
4	The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat - Oliff, Weber, et al. - 1995 (Show Context) Citation Context ...use of CTP to define anterior choroidal artery occlusion has provided the likely explanation for the dichotomous distribution of infarct volumes after intraluminal thread occlusion of the MCA in rats =-=[11,13,14]-=-_ENREF_11. Occluding filament design, variability of vascular anatomy, and occluder tip positioning are likely causes for variability of AChAo. In the current study, variable occlusion of the AChA dur...
4	Somogyvari-Vigh A, Maderdrut JL, Vigh S, Arimura A (2002) Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats. Exp Brain Res 142 - Abraham (Show Context) Citation Context ...rg 4 September 2013 \| Volume 8 \| Issue 9 \| e75779 length and diameter (3 mm60.35 mm, respectively). Previous studies have shown that occluder tips with larger diameters produce larger infarct volumes =-=[8,15,16]-=-. Variability of infarct volumes with different tip lengths has also been investigated [3]. Combined MCAo and AChAo was reported to occur with occluder tip lengths .3.3 mm, but not with shorter tip le...
3	Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats - NJ, Fernandez, et al. - 2006 (Show Context) Citation Context ...) Animal Care and Ethics Committee. Surgical Procedures Male outbred Wistar rats (300–500 g) (Animal Services Unit, UoN) underwent MCAo, using the silicone-tipped intraluminal thread occlusion method =-=[11]-=-. Each 4-0 monofilament occluding thread had a 3 mm silicone tip (0.35 mm diameter). Animals were anesthetized with isoflurane (5% induction, 1.5 – 2.5% maintenance during surgery and 1.0–1.5% during ...
3	Leeuwen M, et al. (2006) Perfusion-CT assessment of infarct core and penumbra - Receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 37: 979–985 - Wintermark, AE, et al. (Show Context) Citation Context ...te the location of the AChA territory. Lack of CBV voxels in the ipsilateral AChA territory (column B, row 2) indicates occlusion of the AChA. For illustrative purposes, a CBV threshold of 2 ml/100 g =-=[19]-=- has been applied to the CBV maps to indicate the areas predicted to infarct within the MCA territory (red). doi:10.1371/journal.pone.0075779.g001 Infarct Volume Variability in Experimental Stroke PLO...
2	DJ, Sing CF - Coyle, Odenheimer - 1984 (Show Context) Citation Context ...niotomy and control over occlusion and reperfusion. One disadvantage of this model is the large variability in infarct volume. Factors thought to influence infarct volume variability include genetics =-=[5]-=-, blood pressure [6], collateral blood flow [7], duration of vessel occlusion, and type of intraluminal thread used [8]. A new observation was made while developing our perfusion computed tomography (...
2	Tsubokawa T, Ohkuma H, Zhang J (2006) Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model. J Neurosci Methods 156:161–165 - Shimamura, Matchett (Show Context) Citation Context ...volume. Factors thought to influence infarct volume variability include genetics [5], blood pressure [6], collateral blood flow [7], duration of vessel occlusion, and type of intraluminal thread used =-=[8]-=-. A new observation was made while developing our perfusion computed tomography (CTP) rat stroke model (intraluminal MCAo) [9,10]. In a subset of animals, there was loss of arterialintensity signal in...
2	TS Jr. (2006) Selective, reversible occlusion of the middle cerebral artery in rats by an intraluminal approach. Optimized filament design and methodology - Ma, Zhao, et al. (Show Context) Citation Context ...ositioning of the occluding thread. Ma et al (2006) demonstrated that the final position of silicone-tipped occluders (with constant tip lengths), varied within and between six different rat strains, =-=[18]-=-. An important question arising from this research is why AChA occlusion is such an important determinant of infarct volume? Infarction within the arterial territory of the AChA itself does not appear...
1	Effect of suture properties on stability of middle cerebral artery occlusion evaluated by synchrotron radiation angiography. Stroke 43: 888–891 - Guan, Wang, et al. - 2012 (Show Context) Citation Context ...y). Previous studies have shown that occluder tips with larger diameters produce larger infarct volumes [8,15,16]. Variability of infarct volumes with different tip lengths has also been investigated =-=[3]-=-. Combined MCAo and AChAo was reported to occur with occluder tip lengths .3.3 mm, but not with shorter tip lengths [3]. However, studies have also shown that the distance between the AChA and MCA is ...
1	Bernaudin M, Touzani O (2010) Impact of genetic and renovascular chronic arterial hypertension on the acute spatiotemporal evolution of the ischemic penumbra: a sequential study with MRI in the rat - Letourneur, Roussel, et al. (Show Context) Citation Context ...over occlusion and reperfusion. One disadvantage of this model is the large variability in infarct volume. Factors thought to influence infarct volume variability include genetics [5], blood pressure =-=[6]-=-, collateral blood flow [7], duration of vessel occlusion, and type of intraluminal thread used [8]. A new observation was made while developing our perfusion computed tomography (CTP) rat stroke mode...
1	Pappada GB, Papadakis M, Cuccione E, Carone D, et al. (2012) Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke. Experimental neurology 233: 815–820 - Riva (Show Context) Citation Context ...ion. One disadvantage of this model is the large variability in infarct volume. Factors thought to influence infarct volume variability include genetics [5], blood pressure [6], collateral blood flow =-=[7]-=-, duration of vessel occlusion, and type of intraluminal thread used [8]. A new observation was made while developing our perfusion computed tomography (CTP) rat stroke model (intraluminal MCAo) [9,10...
1	Establishing a rodent stroke perfusion computed tomography model - DD, MW, et al. - 2011 (Show Context) Citation Context ...w [7], duration of vessel occlusion, and type of intraluminal thread used [8]. A new observation was made while developing our perfusion computed tomography (CTP) rat stroke model (intraluminal MCAo) =-=[9,10]-=-. In a subset of animals, there was loss of arterialintensity signal in the distribution of the anterior choroidal artery (AChA) on cerebral blood volume (CBV) maps, in addition to the expected loss o...
1	Perfusion computed tomography thresholds defining ischaemic penumbra and infarct core: studies in a rat stroke model. Int J Stroke - DD, MW, et al. - 2013
1	The Rat Brain in Stereotaxic Coorinates - Paxinos, Watson - 1997 (Show Context) Citation Context ...gma) using Adobe Photoshop Version 13.0 (Adobe Systems Incorporated). The Photoshop Warp tool was used to transform the histological outlines to fit the stereotaxic atlas template (Paxinos and Watson =-=[12]-=-). The traced infarct outlines were filled with the same grey colour and the opacity was set to 24%. Sections from subsequent animals were overlaid. Figure 1. Perfusion Computed Tomography (CTP) analy...
1	Inducing stroke in aged, hypertensive, diabetic rats - SS, JA, et al. - 2010 (Show Context) Citation Context ...use of CTP to define anterior choroidal artery occlusion has provided the likely explanation for the dichotomous distribution of infarct volumes after intraluminal thread occlusion of the MCA in rats =-=[11,13,14]-=-_ENREF_11. Occluding filament design, variability of vascular anatomy, and occluder tip positioning are likely causes for variability of AChAo. In the current study, variable occlusion of the AChA dur...
1	DG 3rd, Fisher M - Takano, Tatlisumak, et al. - 1997 (Show Context) Citation Context ...rg 4 September 2013 \| Volume 8 \| Issue 9 \| e75779 length and diameter (3 mm60.35 mm, respectively). Previous studies have shown that occluder tips with larger diameters produce larger infarct volumes =-=[8,15,16]-=-. Variability of infarct volumes with different tip lengths has also been investigated [3]. Combined MCAo and AChAo was reported to occur with occluder tip lengths .3.3 mm, but not with shorter tip le...
1	Naritomi H, Yamawaki T, Liu Q, et al. (2000) Definition of the anterior choroidal artery territory in rats using intraluminal occluding technique - He, SH (Show Context) Citation Context ...to occur with occluder tip lengths .3.3 mm, but not with shorter tip lengths [3]. However, studies have also shown that the distance between the AChA and MCA is variable within and across rat strains =-=[3,17]-=-. Another important variable may be the final positioning of the occluding thread. Ma et al (2006) demonstrated that the final position of silicone-tipped occluders (with constant tip lengths), varied...