Results 1 - 10 of 29

Transcription activator interactions with multiple SWI/SNF subunits

by Kristen E. Neely, Ahmed H. Hassan, Christine E. Brown, Leann Howe, Jerry L. Workman, Kristen E. Neely, Ahmed H. Hassan, Christine E. Brown, Leann Howe, Jerry L. Workman , 2002
"... These include: This article cites 73 articles, 38 of which can be accessed free at: ..."
Abstract - Cited by 43 (2 self) - Add to MetaCart
These include: This article cites 73 articles, 38 of which can be accessed free at:
(Show Context)

Mammalian SWI-SNF complexes contribute to activation of the hsp70

by Ivana L. De La Serna, Kerri A. Carlson, David A. Hill, J. Guidi, Ryan O. Stephenson, Saïd Sif, Robert E. Kingston, Anthony N. Imbalzano, Ivana L. De La Serna, Kerri A. Carlson, David A. Hill, Cynthia J. Guidi, Ryan O. Stephenson, Saïd Sif, Robert E. Kingston, Anthony N. Imbalzano , 2000
"... This article cites 92 articles, 43 of which can be accessed free at: ..."
Abstract - Cited by 28 (10 self) - Add to MetaCart
This article cites 92 articles, 43 of which can be accessed free at:
(Show Context)

Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol 2006

by Shipra Rastogi, Bharat Joshi, Piyali Dasgupta, Mark Morris, Kenneth Wright
"... Prohibitin is a growth regulatory gene that has pleiotropic functions in the nucleus, mitochondria, and cytoplasmic compartments. Earlier studies had proposed a role for prohibitin in modulating cellular senes-cence, but the underlying mechanisms remain unknown. Here we show that senescence induced ..."
Abstract - Cited by 12 (2 self) - Add to MetaCart
Prohibitin is a growth regulatory gene that has pleiotropic functions in the nucleus, mitochondria, and cytoplasmic compartments. Earlier studies had proposed a role for prohibitin in modulating cellular senes-cence, but the underlying mechanisms remain unknown. Here we show that senescence induced by DNA-damaging agents causes the localization of prohibitin to specific heterochromatic foci. Prohibitin could bind to heterochromatin protein 1 (HP1) family proteins and colocalized with HP1 in senescence-associated hetero-chromatic foci. Further, HP1 could synergize with prohibitin to repress E2F1-mediated transcriptional activity. The depletion of prohibitin by small interfering RNA or antisense techniques led to a reduction in the senescent phenotype, correlating with a reduced expression of senescence-associated -galactosidase and fewer numbers of senescence-associated heterochromatic foci. Chromatin immunoprecipitation assays showed that prohibitin is needed for the recruitment of HP1 to E2F1-regulated proliferative promoters, leading to their repression. The ablation of prohibitin prevented the recruitment of HPI, but not Suv39H, to the promoters upon senescence. Prohibitin-mediated recruitment of HP1 occurred in only senescent cells, not in quiescent cells; thus, there is a dichotomy in the recruitment of different corepressors by prohibitin, depending on the type of growth arrest. These studies show that prohibitin plays a vital role in inducing cellular senescence. Primary mammalian cells in culture undergo a period of
(Show Context)

Role for BRG1 in cell cycle control and tumor suppression

by Kristin B. Hendricks, Frances Shanahan, Emma Lees, Updated Information, Kristin B. Hendricks, Frances Shanahan, Emma Lees - Mol. Cell. Biol , 2004
"... This article cites 62 articles, 30 of which can be accessed free ..."
Abstract - Cited by 11 (0 self) - Add to MetaCart
This article cites 62 articles, 30 of which can be accessed free
(Show Context)

The activity of mammalian brm/SNF2� is dependent on a high-mobility-group protein I/Y-like DNA binding domain

by Brigitte Bourachot, Moshe Yaniv, Christian Muchardt, Mol Cell Biol, Brigitte Bourachot, Moshe Yaniv, Christian Muchardt , 1999
"... These include: This article cites 61 articles, 21 of which can be accessed free at: ..."
Abstract - Cited by 8 (0 self) - Add to MetaCart
These include: This article cites 61 articles, 21 of which can be accessed free at:
(Show Context)

The BRG1- and hBRM-Associated Factor BAF57 Induces Apoptosis by Stimulating Expression of the Cylindromatosis Tumor Suppressor Gene†

by Li Wang, Robert A. Baiocchi, Sharmistha Pal, Michael Caligiuri, Saïd Sif, Li Wang, Robert A. Baiocchi, Sharmistha Pal, George Mosialos, Michael Caligiuri, Saïd Sif , 2005
"... This article cites 52 articles, 21 of which can be accessed free ..."
Abstract - Cited by 7 (2 self) - Add to MetaCart
This article cites 52 articles, 21 of which can be accessed free
(Show Context)

Adenovirus E1A specifically blocks SWI/SNFdependent transcriptional activation

by Mary E. Miller, Bradley R. Cairns, Randy S. Levinson, Keith R. Yamamoto, Daniel A. Engel, M. Mitchell Smith , 1996
"... Expression of the adenovirus E1A243 oncoprotein in Saccharomyces cerevisiae produces a slow-growth phe-notype with accumulation of cells in the G1 phase of the cell cycle. This effect is due to the N-terminal and CR1 domains of E1A243, which in rodent cells are involved in triggering cellular transf ..."
Abstract - Cited by 5 (1 self) - Add to MetaCart
Expression of the adenovirus E1A243 oncoprotein in Saccharomyces cerevisiae produces a slow-growth phe-notype with accumulation of cells in the G1 phase of the cell cycle. This effect is due to the N-terminal and CR1 domains of E1A243, which in rodent cells are involved in triggering cellular transformation and also in binding to the cellular transcriptional coactivator p300. A genetic screen was undertaken to identify genes required for the function of E1A243 in S. cerevisiae. This screen identified SNF12, a gene encoding the 73-kDa subunit of the SWI/SNF transcriptional regulatory complex. Mutation of genes encoding known members of the SWI/SNF complex also led to loss of E1A function, suggesting that the SWI/SNF complex is a target of E1A243. Moreover, expression of E1A in wild-type cells specifically blocked transcriptional activation of the INO1 and SUC2 genes, whose activation pathways are distinct but have a common requirement for the SWI/SNF complex. These data demonstrate a specific functional interaction between E1A and the SWI/SNF complex and suggest that a similar interaction takes place in rodent and human cells. The adenovirus E1A gene encodes potent oncoproteins that function as regulators of cellular and viral transcription. In the context of a normal adenovirus replicative cycle in permissive human hosts, the E1A proteins perform two main functions.
(Show Context)

Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism

by Anton Chestukhin, Larisa Litovchick, Katherine Rudich, James A. Decaprio, Updated Information, Anton Chestukhin, Larisa Litovchick, Katherine Rudich, James A. Decaprio , 2001
"... These include: This article cites 87 articles, 53 of which can be accessed free at: ..."
Abstract - Cited by 4 (0 self) - Add to MetaCart
These include: This article cites 87 articles, 53 of which can be accessed free at:
(Show Context)

Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein

by Ann Marie Buchmann, Sathyamangalam Swaminathan, Mol Cell Biol, Ann Marie Buchmann, Sathyamangalam Swaminathan , 1998
"... These include: This article cites 63 articles, 37 of which can be accessed free at: ..."
Abstract - Cited by 3 (0 self) - Add to MetaCart
These include: This article cites 63 articles, 37 of which can be accessed free at:
(Show Context)

ATP-Dependent Chromatin-Remodeling Complexes

by Doi:mol Cell Biol, Jerry L. Workman, Marissa Vignali, Ahmed H. Hassan, Kristen E. Neely, Marissa Vignali, Ahmed H. Hassan, Kristen E. Neely, Jerry, L. Workman
"... This article cites 126 articles, 56 of which can be accessed free ..."
Abstract - Cited by 3 (0 self) - Add to MetaCart
This article cites 126 articles, 56 of which can be accessed free
(Show Context)