Both researchers and industry vendors are exploring the con-cept of systems of interoperable medical devices and health information systems that support safety and enhance clinical functionality. The Integrated Clinical Environment (ICE) has been proposed as an architecture for such systems, and several research and commercial implementations are being developed. Central to ICE concept of safe and flexible plug-and-play interoperability is the notion of an ICE Device Model (DM), which is intended to be a machine-readable meta-data description of a device’s capabilities as exposed in standardized form over its network interface. In this paper, we present an overview of the stakehold-ers and high level goals of the ICE DM as necessary for supporting safe and flexible plug-and-play interoperability. These goals provide the foundation for further refinement by research and industry teams to specific safety and imple-mentation requirements for the ICE DM concept. 1.