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A Golgi-localized Hexose Transporter Is Involved in Heterotrimeric G Protein-mediated Early Development in
, 2006
"... Signal transduction involving heterotrimeric G proteins is universal among fungi, animals, and plants. In plants and fungi, the best understood function for the G protein complex is its modulation of cell proliferation and one of several important signals that are known to modulate the rate at which ..."
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Signal transduction involving heterotrimeric G proteins is universal among fungi, animals, and plants. In plants and fungi, the best understood function for the G protein complex is its modulation of cell proliferation and one of several important signals that are known to modulate the rate at which these cells proliferate is D-glucose. Arabidopsis thaliana seedlings lacking the � subunit (AGB1) of the G protein complex have altered cell division in the hypocotyl and are D-glucose hypersensitive. With the aim to discover new elements in G protein signaling, we screened for gain-of-function suppressors of altered cell proliferation during early development in the agb1-2 mutant background. One agb1-2dependent suppressor, designated sgb1-1 D for suppressor of G protein beta1 (agb1-2), restored to wild type the altered cell division in the hypocotyl and sugar hypersensitivity of the agb1-2 mutant. Consistent with AGB1 localization, SGB1 is found at the highest steady-state level in tissues with active cell division, and this level increases in hypocotyls when grown on D-glucose and sucrose. SGB1 is shown here to be a Golgi-localized hexose transporter and acts genetically with AGB1 in early seedling development.
The Arabidopsis D-Type Cyclin CYCD4 Controls Cell Division in the Stomatal Lineage of the Hypocotyl Epidermis W
"... have been edited and the authors have corrected proofs, but before the final, complete issue is published online. Early posting of articles reduces normal time to publication by several weeks. ..."
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have been edited and the authors have corrected proofs, but before the final, complete issue is published online. Early posting of articles reduces normal time to publication by several weeks.
SCFSKP2B- AND KPC1-DEPENDENT DEGRADATION OF CYCLIN- DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
, 2005
"... iii This dissertation is dedicated to Jingrong Wang, my wife, and Sifa Ren and Demei Zhao, my parents, for their love and support. iv Acknowledgements In the past seven and a half years of my graduate school life, it has been a wonderful and unforgettable journey. I was trained in two laboratories a ..."
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iii This dissertation is dedicated to Jingrong Wang, my wife, and Sifa Ren and Demei Zhao, my parents, for their love and support. iv Acknowledgements In the past seven and a half years of my graduate school life, it has been a wonderful and unforgettable journey. I was trained in two laboratories and at two universities. I studied for four years at the University of Texas (UT) at Austin and for three and a half years at IU-Bloomington. First of all, I would like to thank my advisor, Mark Estelle. I first met Mark in 2000 when I was a student in his Plant Developmental Genetics class at UT-Austin. From his class, I learned the power of genetics to studying plant development, which attracted me to switch to Mark’s lab to pursue my Ph.D. I feel truly lucky to have an advisor like Mark and to work in such a great laboratory. In the past five and a half years, under Mark’s guidance, I have
The RPN1 Subunit of the 26S Proteasome in Arabidopsis Is Essential for Embryogenesis
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Review The developmental context of cell-cycle control in plants
, 2005
"... Plant growth is characterised both by continued growth and organogenesis throughout development, as well as by environmental influences on the rate and pattern of these processes. This necessitates a close relationship between cell cycle control, differentiation and development that can be readily o ..."
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Plant growth is characterised both by continued growth and organogenesis throughout development, as well as by environmental influences on the rate and pattern of these processes. This necessitates a close relationship between cell cycle control, differentiation and development that can be readily observed and studied. The sequencing of the Arabidopsis genome has revealed the full complexity of cell cycle regulators in plants, creating a challenge to understand how these genes control plant growth and differentiation, and how they are integrated with intrinsic and external signals. Here, we review the control of the cell cycle and examine how it is integrated with proliferative activity within meristems, and during the differentiation processes leading to leaf and lateral root formation.
Summary
, 2004
"... Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control ..."
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Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control
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"... We develop an algorithm of constrained inversion of IP data for recovering 3D chargeability in the wavelet domain. The inversion is regularized directly by using a scale dependent objective function, while positivity is achieved through conditions imposed on the multiresolution representation of the ..."
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We develop an algorithm of constrained inversion of IP data for recovering 3D chargeability in the wavelet domain. The inversion is regularized directly by using a scale dependent objective function, while positivity is achieved through conditions imposed on the multiresolution representation of the chargeability so that nearly positive solutions are obtained. Accomplishing the inversion entirely in the wavelet domain leads to an algorithm more efficient than those in the space domain. We illustrate the algorithm using a synthetic 3-D data set here and will also demonstrate its practical application to large field data sets.
RESEARCH ARTICLE A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle
"... Cell cycle control is fundamental in eukaryotic development. Several modeling efforts have been used to integrate the complex network of interacting molecular components involved in cell cycle dynamics. In this paper, we aimed at recovering the regulatory logic upstream of previously known component ..."
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Cell cycle control is fundamental in eukaryotic development. Several modeling efforts have been used to integrate the complex network of interacting molecular components involved in cell cycle dynamics. In this paper, we aimed at recovering the regulatory logic upstream of previously known components of cell cycle control, with the aim of understanding the mechanisms underlying the emergence of the cyclic behavior of such components. We focus on Arabidopsis thaliana, but given that many components of cell cycle regulation are conserved among eukaryotes, when experimental data for this system was not available, we considered experimental results from yeast and animal systems. We are proposing a Boolean gene regulatory network (GRN) that converges into only one robust limit cycle attractor that closely resembles the cyclic behavior of the key cell-cycle molecular compo-nents and other regulators considered here. We validate the model by comparing our in sil-ico configurations with data from loss- and gain-of-function mutants, where the endocyclic behavior also was recovered. Additionally, we approximate a continuous model and recov-ered the temporal periodic expression profiles of the cell-cycle molecular components involved, thus suggesting that the single limit cycle attractor recovered with the Boolean model is not an artifact of its discrete and synchronous nature, but rather an emergent con-sequence of the inherent characteristics of the regulatory logic proposed here. This dynam-ical model, hence provides a novel theoretical framework to address cell cycle regulation in plants, and it can also be used to propose novel predictions regarding cell cycle regulation in other eukaryotes.
