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Diurnal cortisol decline is related to coronary calcification: CARDIA study.
- Psychosom. Med.
, 2006
"... Objective: Chronic stress may be a risk factor for coronary heart disease and is associated with dysregulation of the hypothalamicpituitary-adrenal (HPA) axis. We tested the hypotheses that two markers of HPA axis dysregulation, elevated average level (area under the curve, adjusted for time awake) ..."
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Objective: Chronic stress may be a risk factor for coronary heart disease and is associated with dysregulation of the hypothalamicpituitary-adrenal (HPA) axis. We tested the hypotheses that two markers of HPA axis dysregulation, elevated average level (area under the curve, adjusted for time awake) and diurnal decline of salivary cortisol, were associated with presence of coronary calcification (CaC). Method: Seven hundred eighteen black and white middle-aged adults enrolled in an ancillary study of Coronary Artery Risk Development in Young Adults provided six salivary cortisol samples throughout one full day and had measurements of CaC. Results: The prevalence of any calcification was low, 8.1% in the participants of the ancillary study, with white men having the highest proportion. Average cortisol did not differentiate groups, means ϭ 2.15 and 2.08. Those with any CaC declined approximately 6% per hour in cortisol over the course of the day, whereas those with no CaC declined more than 8% per hour (p Ͻ .003). Those persons with slope scores in the flattest quartile had a greater likelihood of any CaC than did those in the remaining quartiles adjusted for sex-race group, age, smoking, treatment for diabetes, systolic blood pressure, logged triglycerides, average cortisol, and educational attainment (odds ratio ϭ 2.58; 95% confidence interval ϭ 1.26 -5.30). Conclusions: Our results are consistent with the hypothesis that HPA axis dysregulation may affect risk for atherosclerosis.
Blood pressure reactivity to psychological stress and coronary calcification in the coronary artery risk development in young adults study
- Hypertension
, 2006
"... Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published ..."
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Cited by 12 (0 self)
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Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published article for which permission is being requested is located, can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialHypertensionin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: by guest on February 28,
Heightened functional neural activation to psychological stress covaries with exaggerated blood pressure reactivity
- Hypertension
, 2007
"... Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published ..."
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Cited by 8 (2 self)
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Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published article for which permission is being requested is located, can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialHypertensionin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: by guest on February 27,
Risk of Cardiovascular Disease
"... The online version of this article, along with updated information and services, is located on the ..."
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Cited by 3 (0 self)
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The online version of this article, along with updated information and services, is located on the
Childhood Socioeconomic Status and Serotonin Transporter Gene Polymorphism Enhance Cardiovascular Reactivity to Mental Stress
"... Objective: To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as on ..."
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Objective: To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as one mechanism linking stress to the pathogenesis of cardiovascular disease. The more transcriptionally efficient long (L) allele of a polymorphism of the serotonin transporter gene promoter (5HTTLPR) has been found associated with increased risk of myocardial infarction. We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers. Methods: Subjects included 165 normal community volunteers stratified for race, gender, and SES, who underwent mental stress testing. Results: Childhood SES as indexed by Father’s Education Level was associated with larger systolic blood pressure (SBP) (p �.05) and diastolic blood pressure (DBP) (p �.01) responses to mental stress. The L allele was associated with larger SBP (p �.04), DBP (p �.0001), and heart rate (p �.04) responses to mental stress compared with the short (S) allele. Subjects with the SS genotype and high Father’s Education exhibited smaller SBP (5.2 mm Hg) and DBP (2.9 mm Hg) responses than subjects with LL genotype and low Father’s Education (SBP � 13.3 mm Hg, p �.002; DBP � 9.7 mm Hg, p �.0001). Conclusions: Both the 5HTTLPR long allele and low SES, particularly during childhood, are associated with increased CVR to mental stress, which could account, at least in part, for the increased cardiovascular disease risk associated with these characteristics. If confirmed in further research, these characteristics could be used to identify persons who might benefit from preventive interventions. Key words: blood pressure, cardiovascular diseases, genetics, heart rate, environmental
Improving stroke prevention in the french West Indies: limits to lay knowledge of risk factors
- Stroke
, 2010
"... Background and Purpose—We sought to evaluate lay knowledge and understanding of cardiovascular diseases in the ..."
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Background and Purpose—We sought to evaluate lay knowledge and understanding of cardiovascular diseases in the
The Endocrine Society
"... All physicians treating patients aged 50 years and older with a hip, spine or radial fracture or managing the on-going care of patients with a diagnosis of osteoporosis (see measures to specific population characteristics) These clinical performance measures are designed for individual quality impro ..."
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All physicians treating patients aged 50 years and older with a hip, spine or radial fracture or managing the on-going care of patients with a diagnosis of osteoporosis (see measures to specific population characteristics) These clinical performance measures are designed for individual quality improvement. Some of the measures may also be
School burnout and cardiovascular functioning in young adult males: a hemodynamic perspective
, 2013
"... This study investigated aortic and brachial hemodynamic functioning that may link school burnout to cardiovascular risk factors. Methodological improvements from previous research were implemented including (1) statistical control of depressive and anxiety symptoms (2) resting, stress-induced and ca ..."
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This study investigated aortic and brachial hemodynamic functioning that may link school burnout to cardiovascular risk factors. Methodological improvements from previous research were implemented including (1) statistical control of depressive and anxiety symptoms (2) resting, stress-induced and cardiac recovery condition comparisons and (3) use of pulse wave analysis. Forty undergraduate young adult males completed self-report measures of school burnout, trait anxiety and depressive symptoms. Participants then completed a protocol consisting of a 10-min seated rest, 5-min baseline (BASE), 3-min cold pressor test (CPT) and a 3-min recovery period (REC). Indices of brachial and aortic hemodynamics were obtained by means of pulse wave analysis via applanation tonometry. Controlling for anxiety and depressive symptoms, planned contrasts identified no differences in cardiovas-cular parameters at BASE between participants in burnout and non-burnout groups. However, negative changes in hemodynamic indices occurred in burnout participants at CPT and REC as evidenced by increased aortic and brachial systolic and diastolic blood pressures, increased left ventricular work and increased myocardial oxygen consumption. Findings suggest that school burnout symptoms are associated with cardiac hyperactivity during conditions of cardiac stress and recovery and therefore may be associated with the early manifestations of cardiovascular disease. Future studies are suggested to reveal underlying autonomic mechanisms explaining hemodynamics functioning in individuals with school burnout symptomatology. Keywords Cardiovascular, cold pressor test, hemodynamics, pulse wave analysis, school burnout, stress
Depression Is Associated With Decreased Blood Pressure, but Antidepressant Use Increases the Risk for Hypertension
"... Abstract—The present study compared blood pressure levels between subjects with clinical anxiety and depressive disorders with healthy controls. Cross-sectional data were obtained in a large cohort study, the Netherlands Study of Depression and Anxiety (N2981). Participants were classified as contro ..."
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Abstract—The present study compared blood pressure levels between subjects with clinical anxiety and depressive disorders with healthy controls. Cross-sectional data were obtained in a large cohort study, the Netherlands Study of Depression and Anxiety (N2981). Participants were classified as controls (N590) or currently or remittedly depressed or anxious subjects (N2028), of which 1384 were not and 644 were using antidepressants. Regression analyses calculated the contributions of anxiety and depressive disorders and antidepressant use to diastolic and systolic blood pressures, after controlling for multiple covariates. Heart rate and heart rate variability measures were subsequently added to test whether effects of anxiety/depression or medication were mediated by vagal control over the heart. Higher mean diastolic blood pressure was found among the current anxious subjects (0.932; P0.03), although anxiety was not significantly related to hypertension risk. Remitted and current depressed subjects had a lower mean systolic blood pressure (1.74, P0.04 and 2.35, P0.004, respectively) and were significantly less likely to have isolated systolic hypertension than controls. Users of tricyclic antidepressants had higher mean systolic and diastolic blood pressures and were more likely to have hypertension stage 1 (odds ratio: 1.90; 95 % CI: 0.94 to 3.84; P0.07) and stage 2 (odds ratio: 3.19; 95 % CI: 1.35 to 7.59; P0.008). Users of noradrenergic and serotonergic working antidepressants were more likely to have hypertension stage 1. This study shows that depressive disorder is associated with low systolic blood pressure and less hypertension, whereas the use of certain antidepressants is
both blood pressure and hypothalamic pituitary-adrenal axis responses to
, 2015
"... mechanism within the paraventricular nucleus reduces both blood ..."
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