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The nature of progression in Parkinson’s disease: an application of non-linear, multivariate, longitudinal random effects modelling,”
- Article ID e76595,
, 2013
"... Abstract Background: To date, statistical methods that take into account fully the non-linear, longitudinal and multivariate aspects of clinical data have not been applied to the study of progression in Parkinson's disease (PD). In this paper, we demonstrate the usefulness of such methodology ..."
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Abstract Background: To date, statistical methods that take into account fully the non-linear, longitudinal and multivariate aspects of clinical data have not been applied to the study of progression in Parkinson's disease (PD). In this paper, we demonstrate the usefulness of such methodology for studying the temporal and spatial aspects of the progression of PD. Extending this methodology further, we also explore the presymptomatic course of this disease.
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"... ii Parkinson’s disease (PD) is a neurodegenerative disorder most commonly associated with motor symptomatology, yet often presenting with deficits in attention, executive functioning (EF; e.g., planning, mental flexibility, complex attention), anxiety, and depression, with debilitating effects on pa ..."
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ii Parkinson’s disease (PD) is a neurodegenerative disorder most commonly associated with motor symptomatology, yet often presenting with deficits in attention, executive functioning (EF; e.g., planning, mental flexibility, complex attention), anxiety, and depression, with debilitating effects on patients ’ quality of life. Current interventions, including pharmacological and surgical methods show efficacy in motor symptom management, yet produce equivocal results in addressing non-motor dysfunction. The goal of this paper was to describe and investigate the efficacy and patient acceptance of a nonpharmacological intervention for treatment of executive dysfunction (ED) and anxiety in PD, in the context of a case study (the case of Mr. K). Brain and Mind Fitness Program (BMFP) is a short-term intervention, consisting of a combination of cognitive remediation and cognitive behavioral therapy (CBT). BMFP was demonstrated to be fully acceptable to Mr. K, based on ratings of 4 feasibility dimensions (fatigue, effort, progress, and enjoyment). The program also proved to be efficacious in alleviating Mr.
University of Zurich Zurich Open Repository and Archive
"... Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients ..."
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Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients
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"... Enhanced frontal low and high frequ in the resting EEG of parkinsonian nth c ..."
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Enhanced frontal low and high frequ in the resting EEG of parkinsonian nth c
133 PUBLICATIONS 3,178 CITATIONS SEE PROFILE
, 2012
"... Dramatic effects of speech task on motor and linguistic planning in severely dysfluent parkinsonian speech ..."
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Dramatic effects of speech task on motor and linguistic planning in severely dysfluent parkinsonian speech
