We study brane configurations in the presence of orientifold six-planes. After deriving the curves for N = 2 supersymmetric SU(Nc) gauge theories with one flavor in the symmetric or antisymmetric representation and Nf fundamental flavors, we rotate the brane configuration, reducing the supersymmetry to N = 1. For the case of an antisymmetric flavor and less than two fundamental flavors, nonperturbative effects lead to a brane configuration that is topologically a torus. Using the description of the orientifold six-planes as Dn singularities we discuss the Higgs branches for N = 2 brane configurations with Sp/SO gauge groups and the related N = 1 theories with tensor representations. May