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Insertion of a New Transcriptional Unit into the Genome of Mouse Hepatitis Virus
, 1998
"... This article cites 42 articles, 28 of which can be accessed free ..."
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Cited by 14 (1 self)
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This article cites 42 articles, 28 of which can be accessed free
A bulged stem-loop structure in the 39 untranslated region of the genome of the coronavirus mouse hepatitis virus is essential for replication
- J Virol
, 1997
"... The 3 * untranslated region (UTR) of the positive-sense RNA genome of the coronavirus mouse hepatitis virus (MHV) contains sequences that are necessary for the synthesis of negative-strand viral RNA as well as sequences that may be crucial for both genomic and subgenomic positive-strand RNA synthesi ..."
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The 3 * untranslated region (UTR) of the positive-sense RNA genome of the coronavirus mouse hepatitis virus (MHV) contains sequences that are necessary for the synthesis of negative-strand viral RNA as well as sequences that may be crucial for both genomic and subgenomic positive-strand RNA synthesis. We have found that the entire 3 * UTR of MHV could be replaced by the 3 * UTR of bovine coronavirus (BCV), which diverges overall by 31 % in nucleotide sequence. This exchange between two viruses that are separated by a species barrier was carried out by targeted RNA recombination. Our results define regions of the two 3 * UTRs that are functionally equivalent despite having substantial sequence substitutions, deletions, or insertions with respect to each other. More significantly, our attempts to generate an unallowed substitution of a particular portion of the BCV 3 * UTR for the corresponding region of the MHV 3 * UTR led to the discovery of a bulged stem-loop RNA secondary structure, adjacent to the stop codon of the nucleocapsid gene, that is essential for MHV viral RNA replication. Coronaviruses are a family of single-stranded, positive-po-larity RNA viruses having genomes of 26 to 31 kb that are the largest known replicating RNA molecules (36). Upon infec-tion, coronavirus genomic RNA serves as the message for
Utilizing fowlpox virus recombinants to generate defective RNAs of the coronavirus infectious bronchitis virus
, 2000
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"... Viable porcine arteriviruses with deletions proximal to the 3 � end of the genome ..."
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Viable porcine arteriviruses with deletions proximal to the 3 � end of the genome
Characterization of Two Temperature-Sensitive Mutants of Coronavirus Mouse Hepatitis Virus Strain A59 with Maturation
, 1996
"... protein. strain A59 with maturation defects in the spike mutants of coronavirus mouse hepatitis virus Characterization of two temperature-sensitive ..."
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protein. strain A59 with maturation defects in the spike mutants of coronavirus mouse hepatitis virus Characterization of two temperature-sensitive
CONTENT ALERTS
, 2000
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Downloaded from www.microbiologyresearch.org by
, 2016
"... Viable porcine arteriviruses with deletions proximal to the 3 « end of the genome ..."
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Viable porcine arteriviruses with deletions proximal to the 3 « end of the genome
CONTENT ALERTS
, 1997
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CONTENT ALERTS
, 1997
"... This article cites 21 articles, 11 of which can be accessed free at: ..."
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