MicroRNAs (miRNAs) constitute a large family of noncod-ing RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present

(specifically emotion processing and social competence), disruptions in stress-responsive biological regulatory systems, including sympathetic-adrenomedullary and hypothalamic–pituitary–adrenocortical functioning, and poor health behaviors, especially substance abuse. This integrated biobehavioral profile leads

A cell’s behavior is a consequence of the complex interactions between its numerous constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling pathways and regulatory mechanisms to coordinate multiple processes, allowing them to respond to and adapt to an ever

In this paper we introduce a system that combines ontogenetic development and artificial evolution to automatically design robots in a physics-based, virtual environment. Through lesion experiments on the evolved agents, we demonstrate that the evolved genetic regulatory networks from successful

Abstract: This paper examines the connection between the legal environment and financial development, and then traces this link through to long-run economic growth. Countries with legal and regulatory systems that (1) give a high priority to creditors receiving the full present value

As the regulation of public companies has progressively tightened in recent years, many companies have chosen to switch to stock exchanges with lower regulatory requirements. We analyse the consequences of switching for smaller quoted companies, using the unusual regulatory environment in London

in Non-Line-of-Sight (NLOS) environments constitutes a significant research and engineering challenge. Ignoring fading in NLOS environments, we can, in principle, meet the 1Gbps data rate requirement with a single-transmit single-receive antenna wireless system if the product of bandwidth (measured in Hz

Motivation: Discovery of regulatory motifs in unaligned DNA sequences remains a fundamental problem in computational biology. Two categories of algorithms have been developed to identify common motifs from a set of DNA sequences. The first can be called a ‘multiple genes, single species

to their environments, and the interplay between regulatory networks and other cellular processes, such as metabolism. Stochasticity The property of a system whose behaviour depends on probabilities. In a model with stochasticity, a single initial state can evolve into several different trajectories, each

ABSTRACT There is a widespread intuitive sense that different kinds of information spread differently on-line, but it has been difficult to evaluate this question quantitatively since it requires a setting where many different kinds of information spread in a shared environment. Here we study