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Results 1 - 10
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12
Towards a bottom-up modelling approach to the pancreatic β-cell electrophysiology
"... Glucose induced bursts of the membrane potential of pancreatic β-cells are at the origin of substantial intracellular calcium increases which, in turn, trig-ger exocytosis of insulin carrying vesicles. In the context of diabetes type II it is aimed to control vesicle exocytosis. This infers the nece ..."
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metabolism. Novel conclusions about the interplay of the transmembrane cur-rents and specific overexpression or inhibition experiments will be discussed. It will be shown that different proteins are responsible for bursting at different glucose levels. The role of sodium currents is revisited and a possible
Modeling of Electric Stimulation in a Three-Dimensional Isotropic Bidomain RC-Medium: a Rectangular Current Stimulus Case
, 1998
"... Abstract. Laplace equations were used for modeling of electrotonic potential in three-dimensional isotropic double-space RC medium. Solutions of Laplace equations for the case of rectangular cur-rent pulse stimulation using spherical electrode we obtain using Laplace transforms in imaginary space. S ..."
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Cited by 1 (1 self)
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Abstract. Laplace equations were used for modeling of electrotonic potential in three-dimensional isotropic double-space RC medium. Solutions of Laplace equations for the case of rectangular cur-rent pulse stimulation using spherical electrode we obtain using Laplace transforms in imaginary space
Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
"... Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such ..."
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such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the cur-rent stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and pro-poses future therapeutic strategies to modulate
A Kinetic Model with Ordered Cytoplasmic Dissociation for SUC1, an Arabidopsis H+/Sucrose Cotransporter Expressed in Xenopus Oocytes
, 1996
"... Abstract. To elucidate the kinetic properties of the Ara-bidopsis H+/sucrose cotransporter, SUC1, with respect to transmembrane voltage and ligand concentrations, the transport system was heterologously expressed in Xeno-pus laevis oocytes. Steady-state plasma membrane cur-rents associated with tran ..."
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Abstract. To elucidate the kinetic properties of the Ara-bidopsis H+/sucrose cotransporter, SUC1, with respect to transmembrane voltage and ligand concentrations, the transport system was heterologously expressed in Xeno-pus laevis oocytes. Steady-state plasma membrane cur-rents associated
geometry models of the heart and torso
"... Abstract. Although the first measurement of the cardiac magnetic field was reported almost half a century ago mag-netocardiography (MCG) is not yet widely used as a clinical diagnostic technique. With the development of a new gener-ation of magnetoelectric sensors it is believed that MCG will become ..."
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’s electrical activity. This equation is solved for the transmembrane voltage which is in turn used to calculate cur-rent densities at discrete time instants. In subsequent simu-lations these current densities represent primary sources of magnetostatic fields arising from a volume conduction prob
Voltage-dependent and Ca2-activated ion channels in human neutrophils. J Clin Invest 85:491–498
, 1990
"... To investigate the regulation of membrane voltage and trans-membrane ion fluxes in human neutrophils, we studied plasma membrane currents using the whole-cell patch-clamp method. We observed three distinct ion channel currents: (a) a voltage-dependent K+ current, (b) a Ca2"-activated K+ current ..."
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Cited by 7 (0 self)
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+ current, and (c) a Ca2"-activated Cl- current. The voltage-dependent K+ cur-rent was found in cells at rest. Its conductive properties sug-gested an inwardly rectifying channel. The channel was acti-vated at membrane potentials more positive than-60 mV, suggesting that it may determine the resting
RESEARCH ARTICLE Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620
"... TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhi-bition of TMEM16A represents a novel pharmaceutical approach for the treatment of can-cers and metastases. The purpose of t ..."
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). By using patch clamp electrophysiology, we showed that DP inhibited TMEM16A chloride cur-rents in Fisher rat thyroid (FRT) cells that were transfected stably with human TMEM16A and in TMEM16A-overexpressed SW620 cells but did not alter cystic fibrosis transmem-brane conductance regulator (CFTR) chloride
Tii * JoumiAL o PHA*MAc0LO0Y AND EXflRflIENTAL THIRAPei7I5 Co#{231}yiighto1967byTh.Ani.ricsn8ociztyforPhsrmecoloandExp.rimenta1Therapeutics Actions of Flunarizine, a Ca Antagonist, on Ionic Currents in Fragmented Smooth Muscle Cells of the Rabbit Small
, 1986
"... Actions of flunarizine on the Ca inward and K ’ outward cur-rents were Investigated using fragmented smooth musde ceNs (smooth muscle ball) prepared from the longitudinal muscle layer of the rbft Neum. Aun&zine dose dependently inhibfted the Ca inwerd current (lD. = 1.4 pM). The decay of the ..."
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Actions of flunarizine on the Ca inward and K ’ outward cur-rents were Investigated using fragmented smooth musde ceNs (smooth muscle ball) prepared from the longitudinal muscle layer of the rbft Neum. Aun&zine dose dependently inhibfted the Ca inwerd current (lD. = 1.4 pM). The decay
Effect of Lidocaine Hydrochloride on Membrane Conductance in Mammalian Cardiac Purkinje Fibers
, 1972
"... diac Purkinje fibers by decreasing the slope of slow dia-stolic depolarization, but the mechanisms of this effect are poorly understood. To test the proposal that the antiautomatic effect of lidocaine might be mediated by an increase in membrane potassium conductance, trans-membrane voltage (Vm) was ..."
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Cited by 3 (1 self)
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that lidocaine increased membrane chord conductance for the potassium ion (gK). Current-voltage relationships using intracellular cur-rent pulses were performed in choline Tyrode at [K]0 of 0.5, 2.0, and 4.0 mm and, at each [K]0, lidocaine was found to increase membrane slope conductance (GK). The increase in GK
MOLECULAR PAIN
"... mediates a transient current [6,10]. ASIC2a has low sensitivity to acidic pH with a pH0.5 of ~4.4 [11]. ASIC2b USA Full list of author information is available at the end of the articlefamily, are abundantly distributed in the central and per-ipheral neurons [1,2]. All ASICs contain two hydrophobic ..."
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extent depending on the subunit composition of the channels. For example, ASIC1a and ASIC3 are very sensitive to protons with an activation threshold close to pH7.0. ASIC1a has a pH0.5 of ~6.2 and mediates fast decaying, transient cur-rents [8]. ASIC3 has two current components includ-ing a peak
Results 1 - 10
of
12
