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53,703
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
 J. Cell
, 1992
"... Abstract. Programmed cell death (PCD) plays a key role in developmental biology and in maintenance of the steady state in continuously renewing tissues. Currently, its existence is inferred mainly from gel electrophoresis of a pooled DNA extract as PCD was shown to be associated with DNA fragmentati ..."
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Cited by 656 (0 self)
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Abstract. Programmed cell death (PCD) plays a key role in developmental biology and in maintenance of the steady state in continuously renewing tissues. Currently, its existence is inferred mainly from gel electrophoresis of a pooled DNA extract as PCD was shown to be associated with DNA fragmentation. Based on this observation, we describe here the development of a method for the in situ visualization of PCD at the singlecell level, while preserving tissue architecture. Conventional histological sections, pretreated with protease, were nick end labeled with biotinylated poly dU, introduced by terminal deoxyp iaOGrtAMMED cell death 0~D) 1 is a selective process of physiological cell deletion (Wyllie, 1981; Umansky,
Probabilistic Latent Semantic Indexing
, 1999
"... Probabilistic Latent Semantic Indexing is a novel approach to automated document indexing which is based on a statistical latent class model for factor analysis of count data. Fitted from a training corpus of text documents by a generalization of the Expectation Maximization algorithm, the utilized ..."
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Cited by 1207 (11 self)
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Probabilistic Latent Semantic Indexing is a novel approach to automated document indexing which is based on a statistical latent class model for factor analysis of count data. Fitted from a training corpus of text documents by a generalization of the Expectation Maximization algorithm, the utilized model is able to deal with domainspecific synonymy as well as with polysemous words. In contrast to standard Latent Semantic Indexing (LSI) by Singular Value Decomposition, the probabilistic variant has a solid statistical foundation and defines a proper generative data model. Retrieval experiments on a number of test collections indicate substantial performance gains over direct term matching methodsaswell as over LSI. In particular, the combination of models with different dimensionalities has proven to be advantageous.
A scheduling model for reduced CPU energy
 ANNUAL SYMPOSIUM ON FOUNDATIONS OF COMPUTER SCIENCE
, 1995
"... The energy usage of computer systems is becoming an important consideration, especially for batteryoperated systems. Various methods for reducing energy consumption have been investigated, both at the circuit level and at the operating systems level. In this paper, we propose a simple model of job s ..."
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Cited by 550 (3 self)
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The energy usage of computer systems is becoming an important consideration, especially for batteryoperated systems. Various methods for reducing energy consumption have been investigated, both at the circuit level and at the operating systems level. In this paper, we propose a simple model of job scheduling aimed at capturing some key aspects of energy minimization. In this model, each job is to be executed between its arrival time and deadline by a single processor with variable speed, under the assumption that energy usage per unit time, P, is a convex function of the processor speed s. We give an offline algorithm that computes, for any set of jobs, a minimumenergy schedule. We then consider some online algorithms and their competitive performance for the power function P(s) = sp where p 3 2. It is shown that one natural heuristic, called the Average Rate heuristic, uses at most a constant times the minimum energy required. The analysis involves bounding the largest eigenvalue in matrices of a special type.
Investigating the Energy Consumption of a Wireless Network Interface in an Ad Hoc Networking Environment
 In IEEE Infocom
, 2001
"... Energyaware design and evaluation of network protocols requires knowledge of the energy consumption behavior of actual wireless interfaces. But little practical information is available about the energy consumption behavior of wellknown wireless network interfaces and device specifications do not ..."
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Cited by 655 (3 self)
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Energyaware design and evaluation of network protocols requires knowledge of the energy consumption behavior of actual wireless interfaces. But little practical information is available about the energy consumption behavior of wellknown wireless network interfaces and device specifications do not provide information in a form that is helpful to protocol developers. This paper describes a series of experiments which obtained detailed measurements of the energy consumption of an IEEE 802.11 wireless network interface operating in an ad hoc networking environment. The data is presented as a collection of linear equations for calculating the energy consumed in sending, receiving and discarding broadcast and pointto point data packets of various sizes. Some implications for protocol design and evaluation in ad hoc networks are discussed. Keywordsenergy consumption, IEEE 802.11, ad hoc networks I.
The Valuation of Options for Alternative Stochastic Processes
 Journal of Financial Economics
, 1976
"... This paper examines the structure of option valuation problems and develops a new technique for their solution. It also introduces several jump and diffusion processes which have nol been used in previous models. The technique is applied lo these processes to find explicit option valuation formulas, ..."
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Cited by 661 (4 self)
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This paper examines the structure of option valuation problems and develops a new technique for their solution. It also introduces several jump and diffusion processes which have nol been used in previous models. The technique is applied lo these processes to find explicit option valuation formulas, and solutions to some previously unsolved problems involving the pricing ofsecurities with payouts and potential bankruptcy. 1.
Algorithms for Quantum Computation: Discrete Logarithms and Factoring
, 1994
"... A computer is generally considered to be a universal computational device; i.e., it is believed able to simulate any physical computational device with a increase in computation time of at most a polynomial factor. It is not clear whether this is still true when quantum mechanics is taken into consi ..."
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Cited by 1103 (7 self)
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A computer is generally considered to be a universal computational device; i.e., it is believed able to simulate any physical computational device with a increase in computation time of at most a polynomial factor. It is not clear whether this is still true when quantum mechanics is taken into consideration. Several researchers, starting with David Deutsch, have developed models for quantum mechanical computers and have investigated their computational properties. This paper gives Las Vegas algorithms for finding discrete logarithms and factoring integers on a quantum computer that take a number of steps which is polynomial in the input size, e.g., the number of digits of the integer to be factored. These two problems are generally considered hard on a classical computer and have been used as the basis of several proposed cryptosystems. (We thus give the first examples of quantum cryptanalysis.) 1 Introduction Since the discovery of quantum mechanics, people have found the behavior of...
Region Competition: Unifying Snakes, Region Growing, and Bayes/MDL for Multiband Image Segmentation
 IEEE Transactions on Pattern Analysis and Machine Intelligence
, 1996
"... We present a novel statistical and variational approach to image segmentation based on a new algorithm named region competition. This algorithm is derived by minimizing a generalized Bayes/MDL criterion using the variational principle. The algorithm is guaranteed to converge to a local minimum and c ..."
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Cited by 778 (21 self)
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We present a novel statistical and variational approach to image segmentation based on a new algorithm named region competition. This algorithm is derived by minimizing a generalized Bayes/MDL criterion using the variational principle. The algorithm is guaranteed to converge to a local minimum and combines aspects of snakes/balloons and region growing. Indeed the classic snakes/balloons and region growing algorithms can be directly derived from our approach. We provide theoretical analysis of region competition including accuracy of boundary location, criteria for initial conditions, and the relationship to edge detection using filters. It is straightforward to generalize the algorithm to multiband segmentation and we demonstrate it on grey level images, color images and texture images. The novel color model allows us to eliminate intensity gradients and shadows, thereby obtaining segmentation based on the albedos of objects. It also helps detect highlight regions. 1 Division of Appli...
Sequential data assimilation with a nonlinear quasigeostrophic model using Monte Carlo methods to forecast error statistics
 J. Geophys. Res
, 1994
"... . A new sequential data assimilation method is discussed. It is based on forecasting the error statistics using Monte Carlo methods, a better alternative than solving the traditional and computationally extremely demanding approximate error covariance equation used in the extended Kalman filter. The ..."
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Cited by 782 (22 self)
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. A new sequential data assimilation method is discussed. It is based on forecasting the error statistics using Monte Carlo methods, a better alternative than solving the traditional and computationally extremely demanding approximate error covariance equation used in the extended Kalman filter. The unbounded error growth found in the extended Kalman filter, which is caused by an overly simplified closure in the error covariance equation, is completely eliminated. Open boundaries can be handled as long as the ocean model is well posed. Wellknown numerical instabilities associated with the error covariance equation are avoided because storage and evolution of the error covariance matrix itself are not needed. The results are also better than what is provided by the extended Kalman filter since there is no closure problem and the quality of the forecast error statistics therefore improves. The method should be feasible also for more sophisticated primitive equation models. The computati...
KodairaSpencer theory of gravity and exact results for quantum string amplitudes
 Commun. Math. Phys
, 1994
"... We develop techniques to compute higher loop string amplitudes for twisted N = 2 theories with ĉ = 3 (i.e. the critical case). An important ingredient is the discovery of an anomaly at every genus in decoupling of BRST trivial states, captured to all orders by a master anomaly equation. In a particu ..."
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Cited by 545 (60 self)
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We develop techniques to compute higher loop string amplitudes for twisted N = 2 theories with ĉ = 3 (i.e. the critical case). An important ingredient is the discovery of an anomaly at every genus in decoupling of BRST trivial states, captured to all orders by a master anomaly equation. In a particular realization of the N = 2 theories, the resulting string field theory is equivalent to a topological theory in six dimensions, the Kodaira– Spencer theory, which may be viewed as the closed string analog of the Chern–Simon theory. Using the mirror map this leads to computation of the ‘number ’ of holomorphic curves of higher genus curves in Calabi–Yau manifolds. It is shown that topological amplitudes can also be reinterpreted as computing corrections to superpotential terms appearing in the effective 4d theory resulting from compactification of standard 10d superstrings on the corresponding N = 2 theory. Relations with c = 1 strings are also pointed out.
Optimal Capital Structure, Endogenous Bankruptcy, and the Term Structure of Credit Spreads
 THE JOURNAL OF FINANCE, VOL. 51, NO. 3, PAPERS AND PROCEEDINGS OF THE FIFTYSIXTH
, 1996
"... ..."
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