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The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
 Science
, 2000
"... ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting t ..."
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Cited by 529 (13 self)
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mystery. Electron microscopy has contributed to our understanding of ribosome structure ever since the ribosome was discovered. In the last few years, threedimensional (3D) electron microscopic images of the ribosome have been produced at resolutions sufficiently high to visualize many of the proteins
The Macroscopic Behavior of the TCP Congestion Avoidance Algorithm
, 1997
"... In this paper, we analyze a performance model for the TCP Congestion Avoidance algorithm. The model predicts the bandwidth of a sustained TCP connection subjected to light to moderate packet losses, such as loss caused by network congestion. It assumes that TCP avoids retransmission timeouts and alw ..."
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Cited by 648 (18 self)
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and always has sufficient receiver window and sender data. The model predicts the Congestion Avoidance performance of nearly all TCP implementations under restricted conditions and of TCP with SelectiveAcknowledgements over a much wider range of Internet conditions. We verify
Fast Folding and Comparison of RNA Secondary Structures (The Vienna RNA Package)
"... Computer codes for computation and comparison of RNA secondary structures, the Vienna RNA package, are presented, that are based on dynamic programming algorithms and aim at predictions of structures with minimum free energies as well as at computations of the equilibrium partition functions and bas ..."
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Cited by 812 (119 self)
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and base pairing probabilities. An efficient heuristic for the inverse folding problem of RNA is introduced. In addition we present compact and efficient programs for the comparison of RNA secondary structures based on tree editing and alignment. All computer codes are written in ANSI C. They include
Comparison of Multiobjective Evolutionary Algorithms: Empirical Results
, 2000
"... In this paper, we provide a systematic comparison of various evolutionary approaches to multiobjective optimization using six carefully chosen test functions. Each test function involves a particular feature that is known to cause difficulty in the evolutionary optimization process, mainly in conver ..."
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Cited by 605 (39 self)
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, the experimental results indicate a hierarchy of the algorithms under consideration. Furthermore, the emerging effects are evidence that the suggested test functions provide sufficient complexity to compare multiobjective optimizers. Finally, elitism is shown to be an important factor for improving evolutionary
Maximum Likelihood Phylogenetic Estimation from DNA Sequences with Variable Rates over Sites: Approximate Methods
 J. Mol. Evol
, 1994
"... Two approximate methods are proposed for maximum likelihood phylogenetic estimation, which allow variable rates of substitution across nucleotide sites. Three data sets with quite different characteristics were analyzed to examine empirically the performance of these methods. The first, called ..."
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Cited by 540 (28 self)
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, and four such categories appear to be sufficient to produce both an optimum, or nearoptimum fit by the model to the data, and also an acceptable approximation to the continuous dis tribution. The second method, called "fixedrates mod el," classifies sites into several classes according
Distance Metric Learning, With Application To Clustering With SideInformation
 ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS 15
, 2003
"... Many algorithms rely critically on being given a good metric over their inputs. For instance, data can often be clustered in many "plausible" ways, and if a clustering algorithm such as Kmeans initially fails to find one that is meaningful to a user, the only recourse may be for the us ..."
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Cited by 799 (14 self)
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be for the user to manually tweak the metric until sufficiently good clusters are found. For these and other applications requiring good metrics, it is desirable that we provide a more systematic way for users to indicate what they consider "similar." For instance, we may ask them to provide
Exact Sampling with Coupled Markov Chains and Applications to Statistical Mechanics
, 1996
"... For many applications it is useful to sample from a finite set of objects in accordance with some particular distribution. One approach is to run an ergodic (i.e., irreducible aperiodic) Markov chain whose stationary distribution is the desired distribution on this set; after the Markov chain has ..."
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Cited by 548 (13 self)
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has run for M steps, with M sufficiently large, the distribution governing the state of the chain approximates the desired distribution. Unfortunately it can be difficult to determine how large M needs to be. We describe a simple variant of this method that determines on its own when to stop
The JPEG still picture compression standard
 Communications of the ACM
, 1991
"... This paper is a revised version of an article by the same title and author which appeared in the April 1991 issue of Communications of the ACM. For the past few years, a joint ISO/CCITT committee known as JPEG (Joint Photographic Experts Group) has been working to establish the first international c ..."
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Cited by 1128 (0 self)
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widely implemented JPEG method to date, and is sufficient in its own right for a large number of applications. This article provides an overview of the JPEG standard, and focuses in detail on the Baseline method. 1
Primitives for the manipulation of general subdivisions and the computations of Voronoi diagrams
 ACM Tmns. Graph
, 1985
"... The following problem is discussed: Given n points in the plane (the sites) and an arbitrary query point 4, find the site that is closest to q. This problem can be solved by constructing the Voronoi diagram of the given sites and then locating the query point in one of its regions. Two algorithms ar ..."
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Cited by 543 (11 self)
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are given, one that constructs the Voronoi diagram in O(n log n) time, and another that inserts a new site in O(n) time. Both are based on the use of the Voronoi dual, or Delaunay triangulation, and are simple enough to be of practical value. The simplicity of both algorithms can be attributed
Riskmanagement: coordinating corporate investment and financing policies
, 1993
"... This paper develops a general framework for analyzing corporate risk management policies. We begin by observing that if external sources of finance are more costly to corporations than internally generated funds, there will typically be a benefit to hedging: hedging adds value to the extent that it ..."
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Cited by 540 (15 self)
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that it helps ensure that a corporation has sufficient internal funds available to take advantage of attractive investment opportunities. We then argue that this simple observation has wide ranging implications for the design of risk management strategies. We delineate how these strategies should depend
Results 1  10
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