phylogenetic comparison of protein-coding genes, reconstruction of ancestral genes and proteins for molecular restoration studies of extinct life forms, combined analysis of heterogeneous data sets from multiple gene loci, and estimation of species divergence times incorporating uncertainties in fossil

Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version

rironmental change. is put to use by humanity; and about one-quarter of the bird species on Earth have been The measurement of land transformadriven to extinction. By these and other standards, it is clear that we live on a human- tion on a global scale is challenging; changdominated planet. es can

substitutions. In this method, excess transitions, unequal nucleotide frequencies, and variation of substitution rate among different sites are all taken into account. Application of this method to human and chimpanzee data suggested that the transition / transversion ratio for the entire control region was -15

This paper examines whether nancial development facilitates economic growth by scrutinizing one rationale for such a relationship; that nancial development reduces the costs of external nance to rms. Speci cally, we ask whether industrial sectors that are relatively more in need of external nance

The phenomenon of growth, decline and death-aging-has been the source of consider-able speculation (1, 8, 10). This cycle seems to be a more or less direct function of the meta-bolic rate and this in turn depends on the species (animal or plant) on which are super-imposed the factors of heredity

simultaneous inferences concerning which genes were affected by the radiation. Although our focus is on one speci � c experiment, the proposed methods can be applied quite generally. The empirical Bayes inferences are closely related to the frequentist false discovery rate (FDR) criterion. 1.

When a rate of return is regressed on a lagged stochastic regressor, such as a dividend yield, the regression disturbance is correlated with the regressor's innovation. The OLS estimator's "nite-sample properties, derived here, can depart substantially from the standard regression

be com-pared include those of the temperature and partial pressure of CO2(p(CO2) ) dependencies of quantum yield, the variation of compensation point with tem-perature and partial pressure of O2(p(O2)), the de-pendence of net CO 2 assimilation rate on p(CO2) and irradiance, and the influence of p(CO2

common, systems with very small numbers of molecules are important in some applications (e.g., in small biological cells or in surface processes). In both views, most complicated systems with multiple reaction channels and multiple chemical species cannot be solved analytically. There are exact numerical