The author and his associates have been experimenting for the past several years with a programming language and documentation system called WEB. This paper presents WEB by example, and discusses why the new system appears to be an improvement over previous ones.

Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of cDNA fragments, yielding a digital inventory of gene and mRNA isoform expression. Analysis of mappings of sequence reads to exon-exon junctions indicated that 92-94% of human genes undergo alternative splicing (AS), ∼86 % with a minor isoform frequency of 15% or more. Differences in isoform-specific read densities indicated that a majority of AS and of alternative cleavage and polyadenylation (APA) events vary between tissues, while variation between individuals was ∼2- to 3-fold less common. Extreme or ‘switch-like ’ regulation of splicing between tissues was associated with increased sequence conservation in regulatory regions and with generation of full-length open reading frames. Patterns of AS and APA were strongly correlated across tissues, suggesting coordinated regulation of these processes, and sequence conservation of a subset of known regulatory motifs in both alternative introns and 3′ UTRs suggested common involvement of specific factors in tissue-level regulation of both

Context-aware computing is a mobile computing paradigm in which applications can discover and take advantage of contextual information (such as user location, time of day, nearby people and devices, and user activity). Since it was proposed about a decade ago, many researchers have studied this topic and built several context-aware applications to demonstrate the usefulness of this new technology. Context-aware applications (or the system infrastructure to support them), however, have never been widely available to everyday users. In this survey of research on context-aware systems and applications, we looked in depth at the types of context used and models of context information, at systems that support collecting and disseminating context, and at applications that adapt to the changing context. Through this survey, it is clear that context-aware research is an old but rich area for research. The difficulties and possible solutions we outline serve as guidance for researchers hoping to make context-aware computing a reality. 1.

In this article, we review diverse studies of the antecedents, facial display, and social consequences of embarrassment. These studies indicate that embarrassment serves an appeasement function, reconciling social relations when they have gone awry. We then speculate about how embarrassment is elaborated into more complex social interactions, such as teasing and flirtation. We conclude by raising questions about the blush and embarrassment that await empirical consideration.

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We describe a new scalable application-layer multicast protocol, specifically designed for low-bandwidth, data streaming applications with large receiver sets. Our scheme is based upon a hierarchical clustering of the application-layer multicast peers and can support a number of different data delivery trees with desirable properties. We present extensive simulations of both our protocol and the Narada application-layer multicast protocol over Internet-like topologies. Our results show that for groups of size 32 or more, our protocol has lower link stress (by about 25%), improved or similar endto-end latencies and similar failure recovery properties. More importantly, it is able to achieve these results by using orders of magnitude lower control traffic. Finally, we present results from our wide-area testbed in which we experimented with 32-100 member groups distributed over 8 different sites. In our experiments, averagegroup members established and maintained low-latency paths and incurred a maximum packet loss rate of less than 1 % as members randomly joined and left the multicast group. The average control overhead during our experiments was less than 1 Kbps for groups of size 100.

Most current statistical natural language processing models use only local features so as to permit dynamic programming in inference, but this makes them unable to fully account for the long distance structure that is prevalent in language use. We show how to solve this dilemma with Gibbs sampling, a simple Monte Carlo method used to perform approximate inference in factored probabilistic models. By using simulated annealing in place of Viterbi decoding in sequence models such as HMMs, CMMs, and CRFs, it is possible to incorporate non-local structure while preserving tractable inference. We use this technique to augment an existing CRF-based information extraction system with long-distance dependency models, enforcing label consistency and extraction template consistency constraints. This technique results in an error reduction of up to 9 % over state-of-the-art systems on two established information extraction tasks. 1

We seek to build a large collection of images with ground truth labels to be used for object detection and recognition research. Such data is useful for supervised learning and quantitative evaluation. To achieve this, we developed a web-based tool that allows easy image annotation and instant sharing of such annotations. Using this annotation tool, we have collected a large dataset that spans many object categories, often containing multiple instances over a wide variety of images. We quantify the contents of the dataset and compare against existing state of the art datasets used for object recognition and detection. Also, we show how to extend the dataset to automatically enhance object labels with WordNet, discover object parts, recover a depth ordering of objects in a scene, and increase the number of labels using minimal user supervision and images from the web.

Recent advancement in wireless communica- tions and electronics has enabled the develop- ment of low-cost sensor networks. The sensor networks can be used for various application areas (e.g., health, military, home). For different application areas, there are different technical issues that researchers are currently resolving. The current state of the art of sensor networks is captured in this article, where solutions are discussed under their related protocol stack layer sections. This article also points out the open research issues and intends to spark new interests and developments in this field.

Awareness of individual and group activities is critical to successful collaboration and is commonly supported in CSCW systems by active, information generation mecha-nisms separate from the shared workspace. These mechanisms pena~ise information providers, presuppose rel-evance to the recipient, and make access difficult, We discuss a study of shared editor use which suggests that awareness information provided and exploited passively through the shared workspace, allows users to move smoothly between close and loose collaboration, and to assign and coordinate work dynamically. Passive awareness mechanisms promise effective support for collaboration requiring this sort of behaviour, whilst avoiding problems with active approaches.