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Results 1 - 10
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136,977
Functional discovery via a compendium of expression profiles.
- Cell,
, 2000
"... provided that the cellular transcriptional response to frames encode proteins required for sterol metabodisruption of different steps in the same pathway is lism, cell wall function, mitochondrial respiration, or similar, and that there are sufficiently unique transcripprotein synthesis. We also sh ..."
Abstract
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Cited by 547 (9 self)
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dyclonine. sion measurement. Using a comprehensive database of reference profiles, the pathway(s) perturbed by an Introduction uncharacterized mutation would be ascertained by simply asking which expression patterns in the database Systematic approaches for identifying the biological its profile most
Linear models and empirical bayes methods for assessing differential expression in microarray experiments.
- Stat. Appl. Genet. Mol. Biol.
, 2004
"... Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. ..."
Abstract
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Cited by 1321 (24 self)
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Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
- Science
, 1999
"... Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumors to known classes (class prediction). Here, a generic approach to cancer classification based on gene expression monitori ..."
Abstract
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Cited by 1779 (19 self)
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derived class predictor was able to determine the class of new leukemia cases. The results demonstrate the feasibility of cancer classification based solely on gene expression monitoring and suggest a general strategy for discovering and predicting cancer classes for other types of cancer, independent
Support Vector Machine Classification and Validation of Cancer Tissue Samples Using Microarray Expression Data
, 2000
"... Motivation: DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data ..."
Abstract
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Cited by 569 (1 self)
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, and other normal tissues. The dataset consists of expression experiment results for 97 802 cDNAs for each tissue. As a result of computational analysis, a tissue sample is discovered and confirmed to be wrongly labeled. Upon correction of this mistake and the removal of an outlier, perfect classification
A Bayesian Framework for the Analysis of Microarray Expression Data: Regularized t-Test and Statistical Inferences of Gene Changes
- Bioinformatics
, 2001
"... Motivation: DNA microarrays are now capable of providing genome-wide patterns of gene expression across many different conditions. The first level of analysis of these patterns requires determining whether observed differences in expression are significant or not. Current methods are unsatisfactory ..."
Abstract
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Cited by 491 (6 self)
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due to the lack of a systematic framework that can accommodate noise, variability, and low replication often typical of microarray data. Results: We develop a Bayesian probabilistic framework for microarray data analysis. At the simplest level, we model log-expression values by independent normal
Comprehending Monads
- Mathematical Structures in Computer Science
, 1992
"... Category theorists invented monads in the 1960's to concisely express certain aspects of universal algebra. Functional programmers invented list comprehensions in the 1970's to concisely express certain programs involving lists. This paper shows how list comprehensions may be generalised t ..."
Abstract
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Cited by 521 (18 self)
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to an arbitrary monad, and how the resulting programming feature can concisely express in a pure functional language some programs that manipulate state, handle exceptions, parse text, or invoke continuations. A new solution to the old problem of destructive array update is also presented. No knowledge
Model-Based Analysis of Oligonucleotide Arrays: Model Validation, Design Issues and Standard Error Application
, 2001
"... Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure of ..."
Abstract
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Cited by 775 (28 self)
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Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure
Making the most of statistical analyses: Improving interpretation and presentation
- American Journal of Political Science
, 2000
"... Social scientists rarely take full advantage of the information available in their statistical results. As a consequence, they miss opportunities to present quantities that are of greatest substantive interest for their research and express the appropriate degree of certainty about these quantities. ..."
Abstract
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Cited by 600 (26 self)
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Social scientists rarely take full advantage of the information available in their statistical results. As a consequence, they miss opportunities to present quantities that are of greatest substantive interest for their research and express the appropriate degree of certainty about these quantities
Symbolic Model Checking for Real-time Systems
- INFORMATION AND COMPUTATION
, 1992
"... We describe finite-state programs over real-numbered time in a guarded-command language with real-valued clocks or, equivalently, as finite automata with real-valued clocks. Model checking answers the question which states of a real-time program satisfy a branching-time specification (given in an ..."
Abstract
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Cited by 578 (50 self)
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, many standard program properties, such as response for all nonzeno execution sequences (during which time diverges), cannot be characterized by fixpoints: we show that the expressiveness of the timed -calculus is incomparable to the expressiveness of timed CTL. Fortunately, this result does
Automatic verification of finite-state concurrent systems using temporal logic specifications
- ACM Transactions on Programming Languages and Systems
, 1986
"... We give an efficient procedure for verifying that a finite-state concurrent system meets a specification expressed in a (propositional, branching-time) temporal logic. Our algorithm has complexity linear in both the size of the specification and the size of the global state graph for the concurrent ..."
Abstract
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Cited by 1388 (62 self)
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We give an efficient procedure for verifying that a finite-state concurrent system meets a specification expressed in a (propositional, branching-time) temporal logic. Our algorithm has complexity linear in both the size of the specification and the size of the global state graph for the concurrent
Results 1 - 10
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136,977
