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Linear models and empirical bayes methods for assessing differential expression in microarray experiments.
- Stat. Appl. Genet. Mol. Biol.
, 2004
"... Abstract The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. ..."
Abstract
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Cited by 1321 (24 self)
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of interest. The approach applies equally well to both single channel and two color microarray experiments. Consistent, closed form estimators are derived for the hyperparameters in the model. The estimators proposed have robust behavior even for small numbers of arrays and allow for incomplete data arising
An Improved In Situ and Satellite SST Analysis for Climate
- J Clim 15:1609–1625. doi
, 2002
"... A weekly 18 spatial resolution optimum interpolation (OI) sea surface temperature (SST) analysis has been produced at the National Oceanic and Atmospheric Administration (NOAA) using both in situ and satellite data from November 1981 to the present. The weekly product has been available since 1993 a ..."
Abstract
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Cited by 391 (12 self)
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global residual biases of roughly 20.038C. The major improvement in the analysis occurs at high latitudes due to the new sea ice algorithm where local differences between the old and new analysis can exceed 18C. Comparisons with other SST products are needed to determine the consistency of the OI
PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res
, 1992
"... PROSITE is a compilation of sites and patterns found in protein sequences; it can be used as a method of determining the function of uncharacterized proteins translated from genomic or cDNA sequences. In some cases the sequence of an unknown protein is too distantly related to any protein of known s ..."
Abstract
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Cited by 312 (3 self)
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structure to detect its resemblance by overall sequence alignment, but relationships can be revealed by the occurrence in its sequence of a particular cluster of residue types which is variously known as a pattern, motif, signature, or fingerprint. These motifs arise because specific region(s) of a protein
Matters arising
"... from typical Wernicke's aphasia to the later picture of disproportionate but not "pure " alexia and agraphia. The persistent aphasic deficits of paraphasic speech and mildly impaired auditory comprehension still showed the residual fluent aphasia. As stated in our paper, we sought to ..."
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from typical Wernicke's aphasia to the later picture of disproportionate but not "pure " alexia and agraphia. The persistent aphasic deficits of paraphasic speech and mildly impaired auditory comprehension still showed the residual fluent aphasia. As stated in our paper, we sought
Summary Background: Angiosarcoma of residual breast, arising after
"... Angiosarcoma of the residual breast after conservative surgery and radiotherapy for primary carcinoma ..."
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Angiosarcoma of the residual breast after conservative surgery and radiotherapy for primary carcinoma
Memory for goals: an activation-based model
, 2002
"... Goal-directed cognition is often discussed in terms of specialized memory structures like the "goal stack." The goal-activation model presented here analyzes goal-directed cognition in terms of the general memory constructs of activation and associative priming. The model embodies three pr ..."
Abstract
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Cited by 188 (37 self)
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predictive constraints: (1) the interference level, which arises from residual memory for old goals; (1) the strengthening constraint, which makes predictions about time to encode a new goal; and (3) the priming constraint, which makes predictions about the role of cues in retrieving pending goals
Dominant forces in protein folding
- Biochemistry
, 1990
"... T e purpose of this review is to assess the nature and mag-nitudes of the dominant forces in protein folding. Since proteins are only marginally stable at room temperature, ’ no type of molecular interaction is unimportant, and even small interactions can contribute significantly (positively or nega ..."
Abstract
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Cited by 176 (2 self)
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or nega-tively) to stability (Alber, 1989a,b; Matthews, 1987a,b). However, the present review aims to identify only the largest forces that lead to the structural features of globular proteins: their extraordinary compactness, their core of nonpolar resi-dues, and their considerable amounts of internal
HIGHER ORDER RENORMALONS a
"... A systematic method of summing the corrections to the renormalon residue arising from higher order renormalons is discussed. ..."
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A systematic method of summing the corrections to the renormalon residue arising from higher order renormalons is discussed.
Transitions. When Do They Arise?
"... Abstract. This article decomposes the observed gaps in educational attainment and school-to-work transitions in Belgium between grandchildren of natives and of women of “non-Western” nationality into (i) differences in observed family endowments and (ii) a residual “pure ethnic gap”. It innovates by ..."
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Abstract. This article decomposes the observed gaps in educational attainment and school-to-work transitions in Belgium between grandchildren of natives and of women of “non-Western” nationality into (i) differences in observed family endowments and (ii) a residual “pure ethnic gap”. It innovates
Results 1 - 10
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