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Results 1 - 10
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543
A gene-coexpression network for global discovery of conserved genetic modules
- Science
, 2003
"... To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexp ..."
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Cited by 377 (5 self)
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experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules
Review Quiescence: early evolutionary origins and universality do not imply uniformity
"... Cell cycle investigations have focused on relentless exponential proliferation of cells, an unsustainable situation in nature. Proliferation of cells, whether microbial or metazoan, is interrupted by periods of quiescence. The vast majority of cells in an adult metazoan lie quiescent. As disruptions ..."
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Cell cycle investigations have focused on relentless exponential proliferation of cells, an unsustainable situation in nature. Proliferation of cells, whether microbial or metazoan, is interrupted by periods of quiescence. The vast majority of cells in an adult metazoan lie quiescent
THE INTUITIVE BASIS OF IMPLICATURE: RELEVANCE THEORETIC IMPLICITNESS VERSUS GRICEAN IMPLYING
- PRAGMATICS
, 2002
"... The notion of implicature was first introduced by Grice (1967, 1989), who defined it essentially as what is communicated less what is said. This definition contributed in part to the proliferation of a large number of different species of implicature by neo-Griceans. Relevance theorists have respond ..."
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Cited by 3 (1 self)
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The notion of implicature was first introduced by Grice (1967, 1989), who defined it essentially as what is communicated less what is said. This definition contributed in part to the proliferation of a large number of different species of implicature by neo-Griceans. Relevance theorists have
An implied latent position process for doubly stochastic messaging activities
"... Abstract—This paper studies the problem of identifying an inhomogeneous interaction structure amongst social agents. We construct the social network by a random graph and model the messaging activities via a multi-channel self-exciting point process. We design a methodology that divides the agents i ..."
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- Social network; Multiple self-exciting point pro-cesses; Hypothesis testing; Risk mitigation. In this paper, we propose a model to estimate and analyze the structure of messaging activities in a social network. This is motivated by the recent proliferation of mobile
Strategic Ambiguity and Arms Proliferation
"... A big power is facing a small power that may have developed weapons of mass destruction. The small power can create strategic ambiguity by refusing arms inspections. We study the impact of strategic ambiguity on arms proliferation and welfare. Strategic ambiguity is a substitute for actually acquiri ..."
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Cited by 9 (3 self)
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are particularly costly. Tough messages that trigger inspections always imply a greater risk of arms proliferation. I.
Materials for an exploratory theory of the network society.
- The British Journal of Sociology
, 2000
"... ABSTRACT This article aims at proposing some elements for a grounded theor y of the network society. The network society is the social structure characteristic of the Information Age, as tentatively identi ed by empirical, cross-cultural investigation. It permeates most societies in the world, in v ..."
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Cited by 122 (0 self)
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of social structure that I call the network society for reasons that hopefully will become apparent. I shall summarize below the main features of these transformations, in a sequential order that does not imply hierarchy of causation in any way. We have entered a new technological paradigm, centred around
Leptin stimulates rat aortic smooth muscle cell proliferation and migration
- Kobe J Med Sci
"... muscle cells Leptin, a peptide secreted from adipose tissue, plays an important role in the regulation of food intake and energy expenditure. In obese patients, plasma leptin levels are elevated and obesity is one of the major risk factors for cardiovascular diseases. Therefore, in this study, we in ..."
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Cited by 38 (0 self)
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investigated the effect of leptin on vascular smooth muscle cell (VSMC) functions. Cultured rat aortic VSMC expressed 130-kDa short form of leptin receptor. Leptin stimulated both proliferation and migration of VSMC. Leptin stimulated phosphorylation and activation of mitogen-activated protein (MAP) kinases
THE PROLIFERATION OF PLASMA CELLS FROM MOUSE
, 1971
"... Recent studies on the development of antibody-forming cells have implied cellular interaction among two or three cell types. Claman et al. (1) proposed synergistic interaction between thymus and bone marrow cells in hemolysin production in irradiated mice transplanted with either or both sorts of ce ..."
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Recent studies on the development of antibody-forming cells have implied cellular interaction among two or three cell types. Claman et al. (1) proposed synergistic interaction between thymus and bone marrow cells in hemolysin production in irradiated mice transplanted with either or both sorts
Modelling physiological and pharmacological control on cell proliferation to optimise cancer treatments
, 2009
"... This review aims at presenting a synoptic, if not exhaustive, point of view on some of the problems encountered by biologists and physicians who deal with natural cell proliferation and disruptions of its physiological control in cancer disease. It also aims at suggesting how mathe-maticians are nat ..."
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Cited by 16 (8 self)
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population dynamics with natural built-in control targets (which im-plies modelling the cell division cycle), together with the distribution of drugs in the organism and their molecular actions on different targets at the cell level on proliferation, i.e., molecular pharmacokinetics
Control of cell proliferation in human glioma by glucocorticoids
- Br. J. Cancer
, 1980
"... Summary.-Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of-2 5 x 10-5M (10 ug/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of in ..."
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Cited by 2 (0 self)
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extensively in cancer chemotherapy and have been shown frequently to be cytostatic. For example, the proliferation of L5178Y mouse lymphoma cells is inhibited when the appropriate steroid receptors are present, implying a specific physiological action (Kondo et al., 1975; Taira & Terayama, 1978). Although
Results 1 - 10
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543
