experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules

Cell cycle investigations have focused on relentless exponential proliferation of cells, an unsustainable situation in nature. Proliferation of cells, whether microbial or metazoan, is interrupted by periods of quiescence. The vast majority of cells in an adult metazoan lie quiescent

The notion of implicature was first introduced by Grice (1967, 1989), who defined it essentially as what is communicated less what is said. This definition contributed in part to the proliferation of a large number of different species of implicature by neo-Griceans. Relevance theorists have

- Social network; Multiple self-exciting point pro-cesses; Hypothesis testing; Risk mitigation. In this paper, we propose a model to estimate and analyze the structure of messaging activities in a social network. This is motivated by the recent proliferation of mobile

are particularly costly. Tough messages that trigger inspections always imply a greater risk of arms proliferation. I.

of social structure that I call the network society for reasons that hopefully will become apparent. I shall summarize below the main features of these transformations, in a sequential order that does not imply hierarchy of causation in any way. We have entered a new technological paradigm, centred around

investigated the effect of leptin on vascular smooth muscle cell (VSMC) functions. Cultured rat aortic VSMC expressed 130-kDa short form of leptin receptor. Leptin stimulated both proliferation and migration of VSMC. Leptin stimulated phosphorylation and activation of mitogen-activated protein (MAP) kinases

Recent studies on the development of antibody-forming cells have implied cellular interaction among two or three cell types. Claman et al. (1) proposed synergistic interaction between thymus and bone marrow cells in hemolysin production in irradiated mice transplanted with either or both sorts

population dynamics with natural built-in control targets (which im-plies modelling the cell division cycle), together with the distribution of drugs in the organism and their molecular actions on different targets at the cell level on proliferation, i.e., molecular pharmacokinetics

extensively in cancer chemotherapy and have been shown frequently to be cytostatic. For example, the proliferation of L5178Y mouse lymphoma cells is inhibited when the appropriate steroid receptors are present, implying a specific physiological action (Kondo et al., 1975; Taira & Terayama, 1978). Although