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unknown title

by B Ortel, N Chen, J Brissette, Gp Dotto, E Maytin, T Hasan
"... protoporphyrin IX accumulation in primary mouse keratinocytes ..."
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protoporphyrin IX accumulation in primary mouse keratinocytes

Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

by T. Ikushima, H. Aritomi, J. Morisita, Mutat Res, R. P. Cunningham, G. W. Teebor, J. Biol Chem, Y. W. Kow, S. S. Wallace, B. Van Houten, H. C. Kung, P. H. Bolton, A. Sancar, Proc Natl, We Thank N. Dovichi, S. Hrudey, T. Lindahl For, O Di Cunto, Gabrielle Topley, Enzo Calautti, Jimmy Hsiao, Lydia Ong, Prem K. Seth, G. Paolo Dotto , 1998
"... bacher, and S. Kuny for technical assistance. Sup-ported by grants from the Natural Sciences and En- ..."
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bacher, and S. Kuny for technical assistance. Sup-ported by grants from the Natural Sciences and En-

Transcriptional Regulation of Intracellular IL-1 Receptor Antagonist Gene by IL-1a in Primary Mouse Keratinocytes

by Eunhye La, Susan M. Fischer, Eunhye La, Susan M. Fischer , 2014
"... is published twice each month byThe Journal of Immunology ..."
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is published twice each month byThe Journal of Immunology

Tyrosine phosphorylation and src family kinases control keratinocyte cell–cell adhesion

by Enzo Calautti, Sara Cabodi, Paul L. Stein, Mechthild Hatzfeld, Nancy Kedersha, G. Paolo Dotto - J. Cell Biol , 1998
"... Abstract. In their progression from the basal to upper differentiated layers of the epidermis, keratinocytes undergo significant structural changes, including establishment of close intercellular contacts. An important but so far unexplored question is how these early structural events are related t ..."
Abstract - Cited by 22 (1 self) - Add to MetaCart
to the biochemical pathways that trigger differentiation. We show here that �-catenin, �-catenin/plakoglobin, and p120-Cas are all significantly tyrosine phosphorylated in primary mouse keratinocytes induced to differentiate by calcium, with a time course similar to that of cell junction formation. Together

ULTRAVIOLET B IRRADIATION AND ACTIVATION OF PROTEIN KINASE D IN PRIMARY MOUSE EPIDERMAL KERATINOCYTES

by Senthil N. Arun, Ph. D, Ismail Kaddour-djebbar, Brian A. Shapiro, Ph. D, Wendy B. Bollag, Ph. D
"... Our previous studies demonstrated that protein kinase D (PKD), a serine/threonine kinase implicated in various cell processes, is up-regulated in basal cell carcinoma (BCC), supporting a possible tumorigenic role for PKD in skin. Since the greatest risk factor for BCC is sun exposure, the ability of ..."
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of ultraviolet B (UVB) irradiation to activate PKD in primary mouse keratinocytes was investigated. Using western analysis with two autophosphorylation-specific antibodies, we show for the first time that UVB activated PKD in a time- and dose-dependent manner. UVB-induced PKD activation was verified using

Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro

by Andrzej A. Dlugosz, Stuart H. Yuspa, Contact The Aacr Publications, Andrzej A. Dlugosz-and, Stuart H. Yuspa - Cancer Res , 1991
"... Staurosporine is a potent but nonselective inhibitor of protein kinase C (PKC) and blocks responses to 12-0-tetradecanoylphorbol-13-acetate (TPA) in several cell types in vitro. In cultured primary mouse keratinocytes, however, Staurosporine fails to inhibit TPA-mediated keratinocyte maturation and ..."
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Staurosporine is a potent but nonselective inhibitor of protein kinase C (PKC) and blocks responses to 12-0-tetradecanoylphorbol-13-acetate (TPA) in several cell types in vitro. In cultured primary mouse keratinocytes, however, Staurosporine fails to inhibit TPA-mediated keratinocyte maturation

Distinct Effects of Different Phosphatidylglycerol Species on Mouse Keratinocyte Proliferation

by Mutsa Seremwe, John G. Edwards, Wendy B. Bollag
"... We have previously shown that liposomes composed of egg-derived phosphatidylglycerol (PG), with a mixed fatty acid composition (comprising mainly palmitate and oleate), inhibit the proliferation and promote the differentiation of rapidly dividing keratinocytes, and stimulate the growth of slowly pro ..."
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proliferating epidermal cells. To determine the species of PG most effective at modulating keratinocyte proliferation, primary mouse keratinocytes were treated with different PG species, and proliferation was measured. PG species containing polyunsaturated fatty acids were effective at inhibiting rapidly

ABSTRACT OF THE DISSERTATION Responses of murine keratinocytes to oxidative stress

by Adrienne T. Black, Jeffrey D. Laskin, T. Black, Jeffrey D. Laskin , 2007
"... Oxidative stress is well recognized as a major contributing factor in the development of cutaneous disease. The generation of reactive oxygen intermediates (ROI) damage cellular macromolecules, causing mutagenic DNA lesions, altered enzyme function, lipid peroxidation and inappropriate signaling. In ..."
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on the expression of antioxidant and arachidonic acid metabolism enzymes in undifferentiated and calcium-differentiated primary mouse keratinocytes. Using enzyme assays, we found that both UVB (2.5-25 mJ/cm2) and paraquat (100 μM) generated ROI and were effective inducers of oxidative stress in these cells

Efficient Down-Regulation of Cyclin A-Associated Activity and Expression in Suspended Primary Keratinocytes Requires p21Cip1

by unknown authors
"... When suspended in methylcellulose, primary mouse keratinocytes cease proliferation and differentiate. Suspension also reduces the activity of the cyclin-dependent kinase cdk2, an important cell cycle regulatory enzyme. To determine how suspension modulates these events, we examined its effects on wi ..."
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When suspended in methylcellulose, primary mouse keratinocytes cease proliferation and differentiate. Suspension also reduces the activity of the cyclin-dependent kinase cdk2, an important cell cycle regulatory enzyme. To determine how suspension modulates these events, we examined its effects

Cripto-1 Alters Keratinocyte Differentiation via Blockade of Transforming Growth Factor-B1 Signaling: Role in

by Skin Carcinogenesis
"... Cripto-1 is an epidermal growth factor-Cripto/FRL1/ Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cripto-1 is highly up-regulated in tumor promoter– ..."
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– treated normal skin and in benign papillomas. Treatment of primary mouse keratinocytes with Cripto-1 stimulated proliferation and induced expression of keratin 8 but blocked induction of the normal epidermal differentiation marker keratin 1, changes that are hallmarks of tumor progression in squamous
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