for a minimum of 10 years. Analysis of expert performance provides unique evidence on the potential and limits of extreme environmental adaptation and learning. Our civilization has always recognized exceptional individuals, whose performance in sports, the arts, and science is vastly superior

to be potentially valuable to detect change in life satis-faction during the course of clinical intervention. Further, the scale shows discrim-inant validity from emotional well-being measures. The SWLS is recommended as a complement to scales that focus on psychopathology or emotional well-being because

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Neuropathic pain (NP) is a wide term, associated with damage to peripheral nerves, spinal nerves and to the central nervous system (CNS). It is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. It is characterised by allodynia, hyperalgesia and hyperpathia leading to sympathetic dysfunction and dystrophic changes. Number of synthetic drugs are used in the management of neuropathic pain but are of no use as they elicit several adverse effects. Hence the present review delineated with the management of neuropathic pain by the aid of herbal drugs and few newer synthetic drugs that are efficacious and potent.

This paper reviews publications and research reports on how sub-Saharan African families have been affected by, and reacted to, the AIDS epidemic. The nature of the African family and its variation across the regions is shown to be basic to both an understanding of how the epidemic spread and of its impact. The volume of good social science research undertaken until now on the disease in Africa is shown to be extremely small relative to the need. The African AIDS epidemic may well be regarded in retrospect as the major event of our time. Almost two-thirds of all HIV-positive persons in the world are in sub-Saharan Africa, the home of only nine per cent of the world’s population. Indeed, most African AIDS sufferers are found in a range of countries from Uganda southward which contain no more than three per cent of the world’s population. Sub-Saharan Africa may well lose as many people to AIDS over the next half century as the Black Death killed in fourteenth-century Europe, although without resulting in the population decline that characterized the earlier epidemic. The African AIDS epidemic differs from that of industrialized countries in that it is very largely heterosexually transmitted. Thus there are at least as many female as male victims in Africa. It is likely

exists to make rapid, measurable progress in child health. This report identifies programmatic interventions that can reduce infant and childhood mortality rates up to 50 % within 12–18 months. These include: • aggressive promotion of exclusive breastfeeding for the first 4-6 months of life • improved

sought to minimize the long-term consequences of impaired kidney function. This review provides an update on the current state of the science and a glimpse toward the future of intervention in sepsis-related acute kidney injury. Clin J Am Soc Nephrol ●●: ●●●-●●●, 2008. doi: 10.2215/CJN.03830907 T he

of potential interventions

evidence of those interventions aimed at modifying the aging process.

and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions. 1. Crosstalk between Inflammatory Pathways and Insulin Signaling 1.1. Mechanism of Insulin Action. Insulin